NanoAssemblr - Precision Nanosystems Benchtop
Overview
Contact: Dmitry Koktysh
ESB 107 - Analytical
615-343-6757
Fee Structure
Get Access - Vanderbilt
Get Access - Non-Vanderbilt
NanoAssemblr Benchtop system provides innovative solutions for the discovery, development and manufacture of novel nanoparticles for use in medical research. It’s designed for rapid prototyping of novel nanoparticle formulations - small molecules, peptides and, nucleic acids into lipid, polymer or hybrid nanoparticles. Non-turbulent microfluidic mixing with precise control over fluid flow rates provides a control over nanoparticle assembly. The software enables the control of input mixing parameters for optimizing particle characteristics such as size and encapsulation efficiency.
Capabilities
- Microfluidics-based manufacture of novel nanoparticles by controlled nanoprecipitation.
- Nucleic acid lipid nanoparticles, liposomes, polymer NPs, emulsions, organic/inorganic NPs
- Isolated fluid path prevents cross-contamination
- Laminar fluid flow and time-invariant mixing
- Rapid mixing (<3 ms)
- <2 min per formulation
- Prepare 1 to 15 mL nanoparticles / run
- Flow rate: 1 mL/min – 18 mL/min
- Syringe compatibility 1, 3, 5, 10 mL
- “Limit Size” is controlled by nanoparticle composition
- Heating controller: 20-70 °C, 3 and 1 mL syringes
Applications
- Lipid, polymer particles manufacturing
- Nanomedicine formulations
- Manufacturing of genetic medicine
- DNA and RNA vaccines