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Vanderbilt Biophotonics Center

Vanderbilt Biophotonics Center
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  5. INS in the Central Nervous System

INS in the Central Nervous System

INSCNSInfrared neural stimulation (INS) is well characterized for the peripheral nervous system; however, translation to the central nervous system (CNS) presents a new set of challenges which require us to consider different anatomy, multiple cell types, and the physiology associated with structures in the CNS.  The current studies designed to optimize INS for  in vivo  stimulation of CNS structures is focused on cortical stimulation.   We have shown that infrared light activates cortex using both optical imaging and electrophysiological techniques.   The implications of this work could lead to neural implants which allows for single cell stimulation making it possible to design closed loop neural interface machines. Additionally, o ur initial work in the brain revealed that infrared light may be effecting more than just neurons in the brain. As it turns out, neurons occupy less half of the brain’s total cell population largely occupied by glial cells and vasculature. Astrocytes, the homeostatic regulators of the brain, and microglia, the immune cells of the brain, appear to be directly modulated by infrared light as well as neurons. In collaboration with  Dr. Valentina Benfenati and Dr. Mark Hutchinson, one area of our lab focuses on (1) how infrared light modulates various glial cells, (2) how this physiologically impacts brain function, (3) how modulating these cells can be used to better understand the multicellular components of brain circuitry and global brain function, and (4) if IR can be used to intervene in neuropathologies such as epilepsy, ischemia, or neurodegenerative disease.

Researchers

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Publications

Cayce, J. M. et al. Calcium imaging of infrared-stimulated activity in rodent brain. Cell Calcium 55, 183–190 (2014).

J. M. Cayce, R. M. Friedman, G. Chen, E. D. Jansen, A. Mahadevan-Jansen, and A. W. Roe, "Infrared neural stimulation of primary visual cortex in non-human primates," Neuroimage, vol. 84C, pp. 181-190, Aug 28 2013.

J. M. Cayce, R. Friedman, E. Jansen, A. Mahadevan-Jansen, and A. Roe, "Functional characterization of infrared neural stimulation in non-human primate cortex," in SPIE Photonics West, San Francisco, 2012, pp. 8207G-149.

J. M. Cayce, R. M. Friedman, E. D. Jansen, A. Mahavaden-Jansen, and A. W. Roe, "Pulsed infrared light alters neural activity in rat somatosensory cortex in vivo," Neuroimage, vol. 57, pp. 155-66, Jul 1 2011.

A. Mahadevan-Jansen, J. M. Cayce, R. Friedman, A. W. Roe, P. E. Konrad, E. Hillman, and E. Jansen, "Imaging optically induced neural activity in the brain," Conf Proc IEEE Eng Med Biol Soc, vol. 2010, pp. 3379-81, 2010.

Cayce JM, Kao CC, Malphrus JD, Konrad PE, Jansen ED, Mahadevan-Jansen A, Optical stimulation of thalamocortical brain slices, IEEE J Spec Topics Quantum Electr 16(3): 565-72 (2010).

Cayce JM, Friedman R, Roe A, Jansen ED, Konrad PE, Mahadevan-Jansen A, Infrared Neural Stimulation and Optical Recording of Somatosensory Cortex, In: Photons and Neurons, BiOS 2009, Photonics West, San Jose CA, January 2009.

Cayce JM, Friedman RM, Roe AW, Jansen ED, Konrad PE, Mahadevan-Jansen A - Infrared neural stimulation and optical recording of somatosensory cortex. - SPIE Photonics West San Jose, CA (2009).

Cayce JM, Friedman RM, Remple M, Konrad PE, Jansen ED, Mahadevan-Jansen A, Roe AW. Infrared neural stimulation of the somatosensory cortex of the rat. Society for Neuroscience 2008. Washington DC.

Cayce JM, Kao CC, Malphrus JD, Konrad PE, Jansen ED, Mahadevan-Jansen A – Optical Stimulation of the Central Nervous System in vitro – OSA Topical meeting Biomed, St. Petersburg, FL, March 2008.

Cayce J, Kao CC, Mahadevan G, Malphrus J, Konrad PE, Mahadevan-Jansen A, Jansen ED – Optical Stimulation of Rat Thalamocortical Brain Slices – in: Optical interactions with cells and tissues XIX – SPIE, San Jose, CA (2008).

Kao CC, Cayce JM, Jansen ED, Mahadevan-Jansen A, Konrad PE – Optical evoked high-frequency following action potentials in rat thalamocortical slices (136.1) - Society for neuroscience Annual meeting, Washington DC, November (2008)

Kao C, Cayce JM, Janesn ED, Mahadevan-Jansen A, Konrad PE. Optical evoked high-frequency following action potentials in rat thalamocortical slices. Society for Neuroscience 2008. Washington DC.