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Vanderbilt Biophotonics Center

Vanderbilt Biophotonics Center
  2. demo2
  3. researchprojects
  4. RS-OCT Detection of Choroidal Melanomas

RS-OCT Detection of Choroidal Melanomas

rsoctThe objective of this project is to develop a dual-modal device to identify precisely depth of the eye-layer within optical coherence tomography (OCT) image and to probe the critical biochemical signatures using Raman spectroscopy (RS). Specifically, we seek to: (1) identify biomarkers to characterize different eye layers using Raman micro-spectroscopy and  (2)  design and development of the dual-modal RS-OCT system to characterize various layers of the rat eye-globe. Biochemical characterization of eye-layers is being accomplished using Raman micro-spectroscopy by modifying a prior RS-OCT system (Patil et al 2011) for fast OCT imaging specifically for in vivo applications and validation of the system using known thickness tissue phantoms.

 

Researchers

     Faculty

      Post Doctoral Scholars

Publications

H. Krishnamoorthi, C. A. Patil, S. Munoz, G. Gutierrez, and A. Mahadevan-Jansen, “Non-destructive measurement of calvaria thickniss with Optical Coherence Tomography,” In preparation.

C. A. Patil, H. Krishnamoorthi, S. Munoz, G. Gutierrez, and A. Mahadevan-Jansen, “Rapid Measurement of Calvaria Volume and Biochemical Properties with Combined Raman Spectroscopy-Optical Coherence Tomography,” In preparation.

H. Krishnamoorthi, C.A. Patil, D.S. Perrien, E.C. O’Quinn, G. Gutierrez, J.S. Nyman, and A. Mahadevan-Jansen. “Optical analysis of physical and biochemical properties of murine calvaria with combined Raman spectroscopy optical coherence tomography.” Paper 7548F-149 presented at SPIE Photonics West, San Francisco, California, January 23-28, 2010.

C.A. Patil, J. Kalkman, D.J. Faber, J.S. Penn, T.G. van Leeuwen, and A. Mahadevan-Jansen “Structural and biochemical characterization of the rat retina with combined Raman spectroscopy optical coherence tomography.” Paper 7550-47 presented at SPIE Photonics West, San Francisco, California, January 23-28, 2010.

C. A. Patil, N. Bosschaart, M. D. Keller, T. G. van Leeuwen, and A. Mahadevan-Jansen, "Combined Raman spectroscopy and opti l coherence tomography device for tissue characterization," Optics Letters, 33 (10), 1135-1137 (2008)http://www.opticsinfobase.org/abstract.cfm?URI=ol-33-10-1135