Photosensitive
Serine Protease Inhibitors
We are interested in inhibitors
for serine proteases (thrombin, Factor Xa, and chymotrypsin),
which are light sensitive. The structural design of our inhibitors
is based on cinnamate derivatives, which upon exposure to light
isomerize and form coumarin derivatives, expelling the free enzyme.
Sub-Group
Member Profiles
Birgit Both birgit.both.1@vanderbilt.edu (Vordiploma (equivalent to BS) Hamburg
University, Germany) Birgit worked for two years in Hamburg
on her Diploma (equivalent to MS).
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Birgit is trying
to shift the absorption of a molecule from the UV region into
the visible light region. |
Derek Pratt
derek.a.pratt@vanderbilt.edu
(B.Sc., Highest
Honors, Carleton
University)
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Derek is currently working on the theoretical
design, synthesis, and study of photolabile serine protease
inhibitors with large two-photon absorbance cross-sections.
The design of these inhibitors, including the modelling of their
docking with various serine proteases is being done in collaboration
with Dr. Jarrod Smith of the Department of Biochemistry. The
two-photon uncaging of the enzymes is being accomplished with
Dr. Sandy Rosenthal of the Department of Chemistry and Dr. David
Piston of the Department of Molecular Physiology and Biophysics.
Before coming to Vanderbilt, Derek worked
with Dr. Keith Ingold at NRC Canada. There he was engaged in
the experimental and theoretical study of substituent effects
on Z-X bond strengths in compounds of the general formula 4-YC4H6Z-X,
bond strenghths in alpha-substituted ketoximes and evaluating
the kinetics of aminophenolic antioxidants. Prior to his experiences
in the Ingold group, Derek worked with Professor Jim Wright
at Carleton University on the development of density functional
theory (DFT)-based models and their application to studies of
the mechanism of antioxidancy of phenolic compounds, and the
design of new phenolic antioxidants related to Vitamin E. For
a closer look at his past and present research, please visit
Derek's
Homepage
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Junhai Yang
junhai.yang@vanderbilt.edu(B.S., M.S., Peking University, P.R.China) |
Junhai is working on enzyme
photoactivation. Junhai worked on Solid Peptides synthesis at
the University of Peking.
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N. A. Porter
Stevenson Professor
Department of Chemistry
Vanderbilt University
Box 1822 Station B
Nashville, TN 37235
Telephone: (800) 288-5400
Fax: (615) 343-5478
n.porter@vanderbilt.edu
webmaster
Last updated 20 June 2001
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