Investigations of Lipid Peroxidation Products

We are studying the oxidative modification of lipid species that are prevalent in biological systems. 

We use Ag+ coordination-ion spray mass spectrometry to identify these oxidized lipids.

Sub-Group Member Profiles

Matt Hangauer (Vanderbilt University undergraduate) matthew.j.hangauer@vanderbilt.edu

 

Matt is working with funding from VUSRP, McMinn Honor Scholarship and a Barry Goldwater scholarship. He is working with Keith Keller (see below).

 

 

 

 

 

 


 

 

Keith Keller keith.a.keller@vanderbilt.edu (B.S., Furman University; Ph.D., University of Virginia)

Currently investigating novel compounds that are intended to convert lipid-soluble peroxyl radicals into water-soluble superoxide radicals.

Keith's doctoral research, under the direction of M. G. Finn, involved the development of novel cleavable linkers for solid phase organic synthesis.

 

 

 

 

 

 

 

 

 

Ginger Lohr ginger.j.lohr@vanderbilt.edu
(B.S.,
Wake Forest University)

 

Ginger is currently investigating the oxidation products of phosphatidylcholine molecular species using Coordination-Ionspray mass spectrometry.

 

Jeremy Mills jeremy.h.mills@vanderbilt.edu (B.S., Vanderbilt University)

Jeremy is examining the peroxidation of benzylic compounds.

Zhiyang Pan zhiyang.pan@vanderbilt.edu (B.S., Peking University, China)

 

 

 

 

 

 

 

 

 

 

 


Zhiyang is working on analysis of lipid peroxidation products by HPLC and MS methods

Bill Roschek bill.roschek@vanderbilt.edu

(B.S. Xavier University, Cincinnati OH)


Bill is studying fragmentation patterns/rates of 9, 12(trans, trans)-methyl linoleate, as well as the synthesis of deuterated hydroxynonenal for further studies in the Mass Spec center.

 

 

 

 

 

 

 

Jennifer Seal jennifer.r.seal@vanderbilt.edu
B.S., Bradley University

 

 

 

 

 

 

Jennifer's work involves Coordination Ionspray Mass Spectrometry. She is doing calibration studies with the ultimate goal of using this mass spec technique for quantitation of lipid peroxide products. 

Sheena Shashikanth Sheena.shashikanth@vanderbilt.edu

Shashi is planning to synthesize nonenal and the corresponding enol and auto oxidation and trying to trap the enols during Hock rearrangement.

 Keri Tallman keri.a.tallman@vanderbilt.edu (B.A., The College of Wooster, Wooster, OH; Ph.D., Colorado State University, under Professor Marc M. Greenberg)

 

Keri is investigating the free radical induced oxidation of lipids. Her work focuses on the use of Coordination Ionspray-MS in the identification of lipid oxidation products and the mechanism by which the hydroperoxides decompose to generate secondary products, such as 4-hydroxynonenal.

Keri's dissertation was "Investigation of the Reactivity of 5,6-Dihydrothymidin-5-yl and its Involvement in DNA Damage Amplification."

 

 

 

 


 

Huiyong Yin huiyong.yin@vanderbilt.edu
(B.S., Tongji University, Shanghai, China, M.S., Organic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China)

Huiyong is currently working on analysis of lipid oxidation products by LC-MS
and GC-MS methods.

His M.S. research centered on synthesis and the study of physical properties of fluorinated liquid crystals under Dr. Jianxun Wen. Huiyong worked on the synthesis of labeled antiferroelectric liquid crystals and mechanistic studies by solid FT-IR, NMR, and Raman while he was a research assistant at the Tokyo Institute of Technology under Dr. Fukuda.

 

 

 

N. A. Porter 
Stevenson Professor
Department of Chemistry
Vanderbilt University
Box 1822 Station B
Nashville, TN 37235
Telephone: (800) 288-5400
Fax: (615) 343-5478

n.porter@vanderbilt.edu


 

 

 webmaster

Last updated 26 August 2001