VISE Summer Instructional Seminar 7.16.20
VISE Research In Progress (RiP)
Date: Thursday, July 2, 2020
Time: Noon – room admittance, 12:05pm remarks, 12:10pm start
Speaker #1:Dewei Hu, PhD Candidate, Department of Electrical Engineering and Computer Science
RiP #1 Title: Retinal OCT Denoising
RIP #1 Description: Retinal optical coherence tomography (OCT) is a powerful cross-sectional visualization tool with vast application in ophthalmic diagnosis. But the imaging technique can give rise to multiplicative speckle noise that hurts essential morphological features. My talk is about developing a learning-based method for retinal OCT denoising.
Speaker #2: J. William Tierney, PhD CandidateDepartment of Biomedical Engineering
RiP #2 Title: MK2 Inhibitory Nano-Polyplexes Inhibit Vascular Graft Failure by Blocking Smooth Muscle Cell Phenotype Switch
RIP #2 Description: Saphenous vein grafts used in patients with coronary or peripheral artery disease have a high rate of failure associated with intimal hyperplasia (IH). One characteristic of IH is the vascular smooth muscle cells (VSMCs) within the graft undergo a contractile-to-synthetic phenotype switch, leading to increased proliferation, migration, and neointima formation that ultimately results in graft failure. In this study we show that MAPK–activated protein kinase 2 inhibitory peptide nanopolyplexes (MK2i-NPs) delivered ex vivo during surgery mitigate IH in vein grafts by blocking VSMC phenotype switch.