VISE Spring Seminar Yuxiao Zhou, PhD, 4.4.24
Yuziao Zhou, PhD,
Assistant Professor
J. Mike Walker ’66 Department of Mechanical Engineering
Texas A&M University
Date: Thursday, April 4, 2024
Time: 11:45 a.m. Lunch, 12:00 p.m. start
Location: Stevenson 5326
Title:
Imaging-based orthopaedic surgery planning and multi-scale bone biomechanics
Abstract:
Bone is a living tissue that senses and responds to external mechanical stimuli by adjusting its mass and geometry via bone remodeling. Mechanical stimuli on bone outside physiological window causes bone loss due to bone disuse or overuse. Maintaining a biomechanical environment favoring bone formation at surgical site is critical to the post-surgical bone-implant integration and long-term success of orthopaedic surgeries. However, measuring the biomechanical environment in bone at surgical sites is challenging due to the nonhomogeneous structure and the opaque property of bone. Using imaging-based mechanical test method, we were able to experimentally measure the 3D full-field biomechanics in bone after orthopaedic surgeries. Orthopaedic surgeries are often performed to fix or prevent fractures in diseased bones, such as bone with osteoporosis and metastasis. Understanding the pathological fracture mechanism of diseased bone helps establish a more precise description of bone biomechanics. We adopt multi-scale mechanical characterization methods to correlate pathological changes in collagen/mineral phases with tissue-scale fragility. The imaging-based mechanical tests and multi-scale biomechanical characterization together pave way for the development of a precise orthopaedic surgery planning procedure, which has a great potential to facilitate post-surgical bone healing and improve the long-term performance of orthopaedic implants.