ViSE Seminar Series: Assessment of a Combined RF Ablation and Cryo-Anchoring Catheter for Treatment of Mitral Valve Prolapse, SC 5326, Thursday August 29, 12:15. Refreshments provided.
Assessment of a Combined RF Ablation and Cryo-Anchoring Catheter for Treatment of Mitral Valve Prolapse
Speakers:
W. David Merryman, Ph.D.
Assistant Professor
Biomedical Engineering, Pharmacology, Medicine, and Pediatrics
Richard J. Gumina, MD, PhD
Assistant Professor of Medicine
Department of Interventional Cardiology
Date: Wednesday August 28th
Time: 12:15 Social, 12:25 Seminar Start
Place: Stevenson Center, 5326
Abstract:
Mitral valve prolapse is one subtype of mitral valve disease and is often characterized by enlarged leaflets that are thickened and have disrupted collagen architecture. The increased surface area of myxomatous leaflets with mitral valve prolapse leads to mitral regurgitation, and there is need for percutaneous treatment options that avoid open-chest surgery. Radiofrequency ablation is one potential therapy in which resistive heating can be used to reduce leaflet size via collagen contracture. One challenge of using radiofrequency ablation to percutaneously treat mitral valve prolapse is maintaining contact between the radiofrequency ablation catheter tip and a functioning mitral valve leaflet. To meet this challenge, we have developed a radiofrequency ablation catheter with a cryogenic anchor for attachment to leaflets in order to apply radiofrequency ablation. Results presented indicate that a catheter having combined radiofrequency ablation and cryo-anchoring provides a novel percutaneous treatment strategy for mitral valve prolapse and may also be useful for other percutaneous procedures where anchored ablation would provide more precise spatial control.