Overview
The
Vanderbilt Institute for Integrative Biosystems Research and Education (VIIBRE)
is developing automated microfluidic pumps, valves, controls, and sensors for a
wide variety of biomedical applications, primarily at the fluidic-volume scale
of 10’s to 100’s of microliters and flow rates ranging from 0.1 to 100’s of
microliters per minute. While these current devices are hardly at “nano” scale,
we have come to realize that the practical in vitro applications of many
nanotechnologies as sensors and controls are in fact limited by the scale of
the biological experiments that can best benefit from nanotechnologies. Today,
many nanoscience experiments are conducted either in multi-well plates or
free-standing microfluidics. The automation of well plate assays will clearly
benefit from miniature, multi-channel pumps and valves, and often the pumps and
reservoirs that perfuse microfluidic chips are orders of magnitude larger than
the chips themselves. Hence VIIBRE is focusing on technologies that will enable
cutting-edge nanoscience, with a growing emphasis on the use of artificial
intelligence and machine learning to create self-driving laboratories that
operate as robot scientists. Nanoscale sensors and actuators could play an
important role in these “laboratories of the future.”
Awards
-R&D 100 Award for MultiWell MicroFormulator, 2017
-Full Member, Society of Toxicology, 2016
-Fellow, American Association for the Advancement of Science (AAAS), 2010
-Fellow, Institute for Electrical and Electronic Engineers, 2008
-Fellow, Heart Rhythm Society, 2006
-The Nightingale Prize, 2006
-Fellow, Biomedical Engineering Society, 2005
-Fellow of the American Heart Association, 2001
-Fellow, American Institute for Medical and Biological Engineering, 1999
-Thomas Jefferson Award, Vanderbilt University, 1997
-John Simon Guggenheim Fellow, 1992-1993
-Fellow, American Physical Society, 1990
-IR-100 Award for Neuromagnetic Current Probe, 1984
-Alfred P. Sloan Research Fellow, 1980-1982
Selected Publications
AutonoMS: Automated Ion Mobility Metabolomic Fingerprinting. Reder GK, Bjurström E, Brunnsåker D, Kronström F, Lasin P, Tiukova IA, Savolainen O, Dodds J, May J, Wikswo JP, McLean J, King RD, Journal of the American Society for Mass Spectrometry, 35, , (2024) View Abstract
A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models. Singh D, Deosarkar S, Cadogan E, Flemington V, Bray A, Zhang J, Reiserer RS, Schaffer DK, Gerken GB, Britt CM, Werner EM, Gibbons F, Kostrzewski T, Chambers CE, Davies E, Ramos Montaya A, Fok J, Hughe D, Fabre K, Waggoner MP, Wikswo JP, Scott CW, PLOS Biology, 20, e3001624, (2022) View Abstract
A bistable, multiport valve enables microformulators creating microclinical analyzers that reveal aberrant glutamate metabolism in astrocytes derived from a tuberous sclerosis patient. Miller DR, Schaffer DK, Neely MD, McClain ES, Travis AR, Block FE, McKenzie JR, Werner EM, Armstrong L, Markov DA, Bowman AB, Ess KC, Cliffel DE, Wikswo JP, Sensors and Actuators B-Chemical, 341, 129972, (2021) View Abstract
The microfluidic multitrap nanophysiometer for hematologic cancer cell characterization reveals temporal sensitivity of the calcein-AM efflux assay. Byrd TF, Hoang LT, Kim EG, Pfister ME, Werner EM, Arndt SE, Chamberlain JW, Hughey JJ, Nguyen BA, Schneibel EJ, Wertz LL, Whitfield JS, Wikswo JP, Seale KT, Scientific Reports, 4, 5117, (2014) View Abstract
Quantum dot probes for monitoring dynamic cellular response: reporters of T cell activation . Warnement MR, Faley SL, Wikswo JP, Rosenthal SJ, IEEE Transactions on Nanobioscience, 5, 268-272, (2006) View Abstract
Education
Ph.D., Physics, Stanford University, 1975M.S., Physics, Stanford University, 1973
B.A., Physics, University of Virginia, 1970