Overview
The goal of the Lippmann Lab is to model, understand, and ultimately treat neurovascular and neurodegenerative disease. We operate at the intersection of engineering and regenerative medicine, and our projects span many disciplines, including chemical and biological engineering, biochemistry, and neuroscience. To carry out this work, we use a broad range of experimental techniques including human induced pluripotent stem cell differentiation, biomaterials fabrication, genetic engineering, high throughput screening, and molecular selection. We are highly collaborative and enjoy working with other teams at Vanderbilt University to accomplish our goals.
Awards
-Chancellor Faculty Fellowship
-School of Engineering Excellent in Teaching Award
-National Science Foundation CAREER Award
-Chan Zuckerberg Initiative Ben Barres Early Career Acceleration Award
-ChBE Award for Excellence in Teaching
-BrightFocus Foundation Research Award
-NARSAD Young Investigator
Selected Publications
Growth factor free, peptide-functionalized gelatin hydrogel promotes arteriogenesis and attenuates tissue damage in a murine model of critical limb ischemia. Curry CW, Sturgeon SM, O'Grady BJ, Yates A, Kjar A, Paige H, Mowery LS, Katdar KA, Patel R, Mlouk K, Steifbold MR, Vafaie-Partin S, Kawabata A, McKee R, Moore-Lotridge S, Hawkes A, Kusunose J, Gibson-Corley KN, Schmeckpeper J, Schoenecker JG, Caskey CF, Lippmann, ES , Biomaterials, 303, 122397, (2024) View Abstract
Albumin-Binding Aptamer Chimeras for Improved siRNA Bioavailability. Rosch JC, Hoogenboezem EN, Sorets AG, Duvall CL, Lippmann LS, Cell Mol Bioeng, 15, 161-173, (2022) View Abstract
Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin. Kim H, Leng K, Park J, Sorets AG, Kim S, Shostak A, Embalabala RJ, Mlouk K, Katdare KA, Rose IVL, Sturgeon SM, Neal EH, Ao Y, Wang S, Sofroniew MV, Brunger JM, McMahon DG, Schrag MS, Kapmann M, Lippmann ES, Nature Communications, 13, 6581, (2022) View Abstract
Rapid prototyping of cell culture microdevices using parylene-coated 3D prints. O'Grady BJ, Geuy MD, Kim H, Balotin KM, Allchin ER, Florian DC, Bute NN, Scott TE, Lowen GB, Fricker CM, Fitzgerald ML, Guelcher SA, Wikswo JP, Bellan LM, Lippmann ES, Lap on a Chip, 21, 4814-4822, (2021) View Abstract
Development of an N-Cadherin Biofunctionalized Hydrogel to Support the Formation of Synaptically Connected Neural Networks. O'Grady BJ, Balotin KM, Bosworth AM, McClatchey PM, Weinstein RM, Gupta M, Poole KS, Bellan LM, Lippmann ES, ACS Biomaterials Science and Engineering, 6, 5811-5822, (2020) View Abstract
Education
Ph.D., Chemical EngineeringUniversity of Wisconsin
B.S., Chemical Engineering
University of Illinois