Overview
Multianalyte
Microphysiometry for Organs on a Chip
Analytical chemistry often leads the forefront of scientific discovery, as new
instrumentation allows us to perform new experiments. Our group has created
multianalyte microphysiometry by combining microfluidic technologies with
electrochemical detection to study the dynamic behaviors of metabolic pathways.
We are developing new multianalyte microphysiometry methods with applications
in cancer, diabetes, and toxicology. We have added electrochemical detectors
for many metabolic analytes into the microfluidic chamber to give a complete
dynamical picture of the live cell populations including organ on a chip
platforms.
Electrochemistry
on the Nanoscale
Electron transfer in nanometer-size chemical systems is an important process
for the creation of macromolecular electronics. We are interested in the
electrochemistry of metallic nanoparticles, redox proteins like Photosystem I,
and other electroactive nanomaterials that bridge the gap between bulk solids
and discrete molecules in the development of electronic devices using
nanotechnology.
Awards
-Society of Electroanalytical Chemistry (SEAC) Young Investigator Award, 2005
-ACS Younger Chemistry Committee Leadership Development Award, 2004
-Central Texas ACS Local Section Appreciation Award, 1997
-Federation of Analytical Chemistry and Spectroscopy Societies Student Award, 1995
-Hoechst Celanese Excellence Awards in Chemistry, Top UT Chemistry Graduate Student Award, 1995
-George Geisler Excellence Award in Chemistry, University of Dayton, 1992
-Thomas Armstrong Outstanding Electrical Engineering Achievement Award, University of Dayton, 1992
-Horvath/ Steger Excellence Award in Electrical Engineering, University of Dayton, 1992
-ACS Undergraduate Analytical Chemistry Award, 1991
-Patterson College Chemistry Award from the Dayton ACS local section, 1991
-Louis Rose Award- Outstanding Electrical Engineer Junior, University of Dayton, 1990
-John Lucier Award- Outstanding Chemistry Junior, University of Dayton, 1990
-Silver Medal at the 20th International Chemistry Olympiad in Helsinki, Finland, 1988
Selected Publications
Photoactive and conductive biohybrid films by polymerization of pyrrole through voids in photosystem I multilayer films. Passantino JM, Christiansen BA, Nabhan MA, Parkerson ZJ, Oddo TD, Cliffel DE, Jennings GK, Nanoscale Advances, 5, 5301-5308, (2023) View Abstract
Utilizing Toray Paper as a Metal-Free, High Surface Area Electrode for Photosystem I–Driven Mediated Electron Transfer. Stachurski CD, Williams JM, Tabaquin PM, Wood ED, Phambu N, Jennings GK, Cliffel DE, Energy Technology, 11, 2201077, (2023) View Abstract
Adsorption and Electropolymerization of p-Aminophenol Reduces Reproducibility of Electrochemical Immunoassays . Buckey G, Owens OE, Gabriel AW, Downing CM, Calhoun MC, Cliffel DE, Molecules, 27, 6046, (2022) View Abstract
Trace Oxygen Affects Osmium Redox Polymer Synthesis for Wired Enzymatic Biosensors. Calhoun MC, Stachurski CD, Winn SL, Gizzie EA, Daniel AW, Schley ND, Cliffel De, Journal of the Electrochemical Society, 169, 016506, (2022) View Abstract
Chlorpyrifos Disrupts Acetylcholine Metabolism Across Model Blood-Brain Barrier. Miller DR, McClain ES, Dodds JN, Balinski A, May JC, McLean JA, Cliffel DE, Frontiers in Bioengineering and Biotechnology, 9, 622175, (2021) View Abstract
Education
Postdoctoral Scholar, University of North Carolina, 1998-2000Ph.D., University of Texas at Austin, 1998
B.S./B.E.E., University of Dayton, 1992