Overview
The Duvall Advanced Therapeutics
Laboratory applies “smart”, environmentally-responsive polymers to develop
novel approaches for overcoming pharmacological barriers. A variety of projects
are currently underway to develop polymeric systems that respond to one or more
stimuli such as pH, temperature, oxidative stress, and enzymatic activity. We
also employ nucleic acid and protein engineering strategies toward development
of new carrier-free genetic medicines.
Awards
-Fellow of Biomedical Engineering Society, 2020
-Fellow of American Institute for Medical and Biological Engineering (AIMBE), 2018
-Vanderbilt Chancellor’s Faculty Fellow, 2018
-Presidential Early Career Award for Scientists and Engineers (PECASE), 2017
-China-America Frontiers of Engineering NAE Symposium Participant, 2017
-Biomedical Engineering Society (BMES) CMBE Young Innovator Award, 2016
-Society for Biomaterials Young Investigator Award, 2015
-NSF CAREER Award, 2014
Selected Publications
Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy. Hoogenboezem EN, Patel SS, Lo JH, Cavnar AB, Babb LM, Francini N, Gbur EF, Patil P, Colazo JM, Michell DL, Sanchez VM, McCune JT, Ma J, DeJulius CR, Lee LH, Rosch JC, Allen RM, Stokes LD, Hill JL, Vickers KC, Cook RS, Duvall CL, Nature Communications, 15, 1581, (2024) View Abstract
Non-Viral In Vivo Delivery of CRISPR-Cas9 using Protein-Agnostic, High-Loading Porous Silicon and Polymer Nanoparticles. Fletcher RB, Stokes LD, Kelly IB, Henderson KM, Vallecillo-Viejo IC, Colazo JM, Wong BV, Yu F, d’Arcy R, Struthers MN, Evans BC, Ayers J, Castanon M, Weirich MJ, Reilly SK, Patel SS, Ivanova YI, Silvera Batista CA, Weiss SM, Gersbach CA, Brunger JM, Duvall CL, ACS Nano, 17, 16412-16431, (2023) View Abstract
ROS-Degradable Polythioketal Urethane Foam Dressings to Promote Porcine Skin Wound Repair. Patil P, Russo KA, McCune JT, Pollins AC, Cottam MA, Dollinger BR, DeJulius CR, Gupta MK, D'Arcy R, Colazo JM, Yu F, Bezold MG, Martin JR, Cardwell NL, Davidson JM, Thompson CM, Barbul A, Hasty AM, Guelcher SA, Duvall CL, Science Translational Medicine, 14, eabm6586, (2022) View Abstract
An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles. Evans BC, Fletcher RB, Kilchrist KV, Dailing EA, Mukalel AJ, Colazo JM, Oliver M, Cheung-Flynn J, Brophy CM, Tierney JW, Isenberg JS, Hankenson KD, Ghimire K, Lander C, Gersbach CA, Duvall CL, Nature Communications, 10, 5012, (2019) View Abstract
Nano-polyplex MK2 Inhibitory Peptide Delivery Inhibits Vascular Graft Intimal Hyperplasia. Evans BC, Hocking KM, Osgood MJ, Voskresensky I, Dmowska J, Kilchrist KV, Brophy CM, Duvall CL, Science Translational Medicine, 7, 291ra95, (2015) View Abstract
Education
Postdoctoral Training, Bioengineering, University of Washington, 2007-2009Ph.D., Biomedical Engineering, Georgia Institute Tech. and Emory University, 2007
B.S., Biosystems and Agricultural Engineering, University of Kentucky, 2001