“Taxanes Sensitize Prostate Cancer Cells to TRAIL-Induced Apoptotic Synergy via Endoplasmic Reticulum Stress” published in Molecular Cancer Therapeutics has been selected as a VINSE spotlight publication.
About the author: Korie Grayson (koriegrayson.com) earner her PhD in Biomedical Engineering in May 2020 from Cornell University under the direction of Prof. Michael King. She was a visiting graduate student at Vanderbilt University during this time. Korie’s work focused on understanding the mechanisms of metastasis in prostate cancer, and the development of new approaches to treat drug-resistant prostate cancer. In this paper, she demonstrated that the taxane class of chemotherapeutic drug sensitizes prostate cancer cells to cellular apoptosis (programmed cell death) via the protein therapeutic TRAIL. She showed that this TRAIL sensitization occurs via stress to the endoplasmic reticulum, which was verified with a computational model of the signal transduction process. Korie is currently a postdoctoral fellow at the University of Michigan and an active advocate for diversity in STEM fields.