— being rescheduled, date/time TBA
Dr. Vincent Rotello
Distinguished Professor of Chemistry
University of Massachusetts Amherst
“Interfacing nanomaterials with biology: from delivery of biologics to antimicrobials”
Bio
Vincent Rotello has received the Langmuir Lectureship (2010), and in 2016 he received the TREE Award (Research Corporation), the Bioorganic Lectureship (Royal Society of Chemistry, UK), and the Chinese Academy of Sciences, President’s International Fellowship for Distinguished Researchers. He is a Fellow of the American Association for the Advancement of Science (AAAS) and the Royal Society of Chemistry (U.K.). He was also recognized in 2014, 2015, 2018, 2019 and 2020 by Thomson Reuters/Clarivate as “Highly Cited Researcher”. He is currently the Editor in Chief of Bioconjugate Chemistry. His research program focuses on using nanomedicine, with over 600 peer-reviewed papers published to date.
Abstract
A key issue in the use of nanomaterials is controlling how they interact with themselves and with the outer world. Our research program focuses on the tailoring of nanoparticles of surfaces for a variety of applications, coupling the atomic-level control provided by organic synthesis with the fundamental principles of supramolecular chemistry. Using these nanoparticles, we are developing new strategies for biological applications This talk will focus on the interfacing of nanoparticles with biosystems, and will discuss the application of self-assembled nanoparticles and polymers as delivery vehicles. We will demonstrate the delivery of proteins the cytosol. We will also show how this efficient cellular delivery translates into effective systems in vivo. Finally, this presentation will also feature the use of nanoparticles as therapeutics against multi-drug resistant bacteria, providing a potential strategy for combatting this emerging threat.