Technological Advancements
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Abstract
National Library of Medicine National Center for Biotechnology Information
A novel mouse home cage lickometer system reveals sex- and housing-based influences on alcohol drinking
Alcohol use disorder (AUD) is a significant global health issue. Despite historically higher rates among men, AUD prevalence and negative alcohol-related outcomes in women are rising. Loneliness in humans has been associated with increased alcohol use, and traditional rodent drinking models involve single housing, presenting challenges for studying social enrichment.
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Abstract
National Library of Medicine National Center for Biotechnology Information
Structured tracking of alcohol reinforcement (STAR) for basic and translational alcohol research
There is inherent tension between methodologies developed to address basic research questions in model species and those intended for preclinical to clinical translation: basic investigations require flexibility of experimental design as hypotheses are rapidly tested and revised, whereas preclinical models emphasize standardized protocols and specific outcome measures.
Papers
Delineation of an insula-BNST circuit engaged by struggling behavior that regulates avoidance in mice
Alterations in BNST Intrinsic Functional Connectivity in Early Abstinence from Alcohol Use Disorder
Structured tracking of alcohol reinforcement (STAR) for basic and translational alcohol research
Dopamine signaling in the nucleus accumbens core mediates latent inhibition
Anxiety during abstinence from alcohol: A systematic review of rodent and human evidence for the anterior insula's role in the abstinence network
Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits
Endocannabinoid control of the insular-bed nucleus of the stria terminalis circuit regulates negative affective behavior associated with alcohol abstinence
Systemic kappa opioid receptor antagonism accelerates reinforcement learning via augmentation of novelty processing in male mice
Kappa opioid receptor modulation of excitatory drive onto nucleus accumbens fast-spiking interneurons
Research Findings
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Abstract
National Library of Medicine National Center for Biotechnology Information
Alterations in BNST Intrinsic Functional Connectivity in Early Abstinence from Alcohol Use Disorder
Maintaining abstinence from alcohol use disorder (AUD) is extremely challenging, partially due to increased symptoms of anxiety and stress that trigger relapse. Rodent models of AUD have identified that the bed nucleus of the stria terminalis (BNST) contributes to symptoms of anxiety-like behavior and drug-seeking during abstinence. In humans, however, the BNST’s role in abstinence remains poorly understood.
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