Projects

A strength of the Vanderbilt AUD Research and Education Center (VAREC) is the diversity of research questions and experimental approaches which are brought together within a cohesive and interactive framework of clinical and preclinical researchers. Due to the multifaceted nature of AUD, understanding the neural mechanisms underlying many of the AUD-relevant phenotypes requires studies that integrate information from the behavioral, circuit, and molecular levels. VAREC allows for an integration of research aimed at collaboratively answering this complex question.

projects
Section Contents
Project 4

Preclinical approaches for advancing precision applications of kappa-opioid receptor ligands in AUD treatment

This project focuses on identifying precision treatment strategies for alcohol use disorder.

Using forward screening of a library of approved and experimental compounds, the project aims to identify interventions which may not show efficacy when examined across a heterogeneous population, but are particular effective in certain types of drinkers.

The overarching goal is to use these individual characteristics to increase the likelihood that an individual is prescribed with the pharmacological intervention that will yield the greatest therapeutic benefit.

Project Lead

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