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Samantha Pegg


Research Area: Clinical Science


Mood disorders, emotion and reward processing

Samantha Pegg is broadly interested in studying the underlying mechanisms of mood disorders, particularly how alterations in emotional and social processing contribute to the development of these disorders. 

Lab Website

Representative Publications

Peer-Reviewed Publications

Venanzi, L., Dickey, L., Pegg, S., & Kujawa, A. (in press). Delta-beta coupling in adolescents with depression: A preliminary examination of associations with symptom severity and treatment outcomes. Journal of Psychophysiology.

Politte-Corn, M., Dickey, L., Abitante, G., Pegg, S., Bean, C. A. L., & Kujawa, A. (2024). Social media use as a predictor of positive and negative affect: An ecological momentary assessment study of adolescents with and without clinical depression. Research on Child and Adolescent Psychopathology. Advance online publication. https://doi.org/10.1007/s10802-024-01177-x

Dickey, L., Dao, A., Pegg, S., & Kujawa, A. (2024). Neural markers of emotion regulation difficulties in adolescent depression and risk for depression. Journal of Mood & Anxiety Disorders, 5, 100051. https://doi.org/10.1016/j.xjmad.2024.100051

Pegg, S., & Kujawa, A. (2024). The effects of stress on reward responsiveness: A systematic review and preliminary meta-analysis of the event-related potential literature. Cognitive, Affective, and Behavioral Neuroscience, 24, 42-59https://doi.org/10.3758/s13415-023-01143-y

Pegg, S., Dao, A., Venanzi, L., Hill, K., & Kujawa, A. (2024). The impact of electrode selection for ocular correction on the reward positivity and late positive potential components in adolescence. Psychophysiology, 61, e14497. https://doi.org/10.1111/psyp.14497

Long, Y., Dickey, L., Pegg, S., Argiros, A., Venanzi, L., Dao, A., & Kujawa, A. (2024). Interpersonal trauma effects on adolescent depression: The moderating role of neurophysiological responses to positive interpersonal images. Research on Children and Adolescent Psychopathology, 52, 195-206https://doi.org/10.1007/s10802-023-01118-0

Rappaport, B. I., Kujawa, A., Arfer, K. B., Pegg, S., Kelly, D., Jackson, J. J., Luby, J. L., & Barch, D. M. (2024). Behavioral and psychiatric correlates of brain responses to social feedback. Psychophysiology, 61, e14413. https://doi.org/10.1111/psyp.14413

Babinski, D.E., Kujawa, A., Pegg, S., Leslie, J. M., Pothoven, C. Waschbusch, D. A., & Sharp, C. (2023). Social and monetary processing in youth with early emerging personality pathology: An RDoC-informed study. Research on Child and Adolescent Psychopathology. Advance online publication. https://doi.org/10.1007/s10802-023-01147-9

Long, Y., Dickey, L., Pegg, S., Argiros, A., Venanzi, L., Dao, A., & Kujawa, A. (2023). Interpersonal trauma effects on adolescent depression: The moderating role of neurophysiological responses to positive interpersonal images. Research on Children and Adolescent Psychopathology. Advance online publication. https://doi.org/10.1007/s10802-023-01118-0

Rappaport, B. I., Kujawa, A., Arfer, K. B., Pegg, S., Kelly, D., Jackson, J. J., Luby, J. L., & Barch, D. M. (2023). Behavioral and psychiatric correlates of brain responses to social feedback. Psychophysiology. Advance online publication. https://doi.org/10.1111/psyp.14413

Hill, K., Pegg, S., Dao, A., Boldwyn, E., Dickey, L., Venanzi, L., Argiros, A., & Kujawa, A. (2023). Characterizing positive and negative valence systems function in adolescent depression: An RDoC-informed approach integrating multiple neural measures. Journal of Mood and Anxiety Disorders, 3, 100025. https://doi.org/10.1016/j.xjmad.2023.100025

Burkhouse, K., Dao, A., Argiros, A., Granros, M., Cárdenas, E., Dickey, L., Feurer, C., Hill, K., Pegg, S., Venanzi, L., & Kujawa, A. (2023). Targeting positive valence systems function in children of mothers with depressive symptoms: A pilot randomized trial of an RDoC-informed preventive intervention. Behaviour Research and Therapy, 168, 104384. https://doi.org/10.1016/j.brat.2023.104384

Dickey, L., Pegg, S., Cárdenas, E. F., Green, H., Dao, A., Waxmonsky, J., Pérez-Edgar, K., & Kujawa, A. (2023). Neural predictors of improvement with cognitive behavioral therapy for adolescents with depression: An examination of reward responsiveness and emotion regulation. Research on Child and Adolescent Psychopathology. Advance online publication. https://doi.org/10.1007/s10802-023-01054-z

Argiros, A., Venanzi, L., Dao, A., Dickey, L., Herman, N., Pegg, S., Hill, K., Stewart, J., & Kujawa, A. (2023). Social support and parental conflict as predictors of response to group cognitive behavioral therapy for adolescent depression. International Journal of Cognitive Therapy. Advance online publication. https://doi.org/10.1007/s41811-023-00159-z

Babinski, D. E., Pegg, S., West, M., Arfer, K. B., & Kujawa, A. (2023). Borderline personality features and altered social feedback processing in emerging adults: An EEG study. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 120, 110648. https://doi.org/10.1016/j.pnpbp.2022.110648

Hill, K. E., Dickey, L., Pegg, S., Dao, A., Arfer, K. B., & Kujawa, A. (2023). Associations between parental conflict and social and monetary reward responsiveness in adolescents with clinical depression. Research on Child and Adolescent Psychopathology51(1), 119–131. https://doi.org/10.1007/s10802-022-00949-7

Pegg, S., Hill, K., Argiros, A., Olatunji, B. O., & Kujawa, A. (2022). Cognitive behavioral therapy for anxiety disorders in youth: Efficacy, moderators, and new advances in predicting outcomes. Current Psychiatry Reports, 24(12), 853–859. https://doi.org/10.1007/s11920-022-01384-7

Bettis, A. H., Benningfield, M. M., Dao, A., Dickey, L., Pegg, S., Venanzi, L., & Kujawa, A. (2022). Self-injurious thoughts and behaviors and alterations in positive valence systems: A systematic review of the literature. Journal of Psychiatric Research, 156, 579–593. https://doi.org/10.1016/j.jpsychires.2022.10.033

Politte-Corn, M., Nick, E., Dickey, L., Pegg, S., Cole, D. A., & Kujawa, A. (2022). #socialdistancing: Social media use and online social support moderate the effect of pandemic-related stress on internalizing symptoms in emerging adults. Journal of Social and Clinical Psychology, 41, 30-53. https://doi.org/10.1521/jscp.2021.40.6.30

Waxmonsky, J., Fosco, W., Waschbusch, D., Babinski, D., Baweja, R., Pegg, S., Cao, V., Shroff, D., & Kujawa, A. (2022). The impact of irritability and callous unemotional traits on reward positivity in youth with ADHD and conduct problems. Research on Child and Adolescent Psychopathology, 50(8), 1027–1040. https://doi.org/10.1007/s10802-022-00901-9

Pegg, S., Lytle, M. N., Arfer, K. B., & Kujawa, A. (2022). The time course of reactivity to social acceptance and rejection feedback: An examination of event-related potentials and behavioral measures in a peer interaction task. Psychophysiology, 59(7), e14007. https://doi.org/10.1111/psyp.14007

Venanzi, L., Dickey, L., Green, H., Pegg, S., Benningfield, M., Bettis, A., Blackford, J., & Kujawa, A. (2022). Longitudinal predictors of depression, anxiety, suicidal ideation, and alcohol use following COVID-19-related stress. Stress and Health,38(4), 679–691. https://doi.org/10.1002/smi.3125

Dickey, L., Pegg, S. L., & Kujawa, A. (2021). Neurophysiological responses to interpersonal emotional images: Associations with symptoms of depression and social anxiety. Cognitive Affective and Behavioral Neuroscience, 21(6), 1306-1318. https://doi.org/10.3758/s13415-021-00925-6

Kamali, M., Pegg, S., Janos, J. A., Bobo, W. V., Brody, B., Gao, K., Ketter, T. A., McElroy, S. L., McInnis, M. G., Rabideau, D., Reilly-Harrington, N., Shelton, R. C., Sylvia, L. G., Tohen, M., & Nierenberg, A. (2021). Illness stage and predominant polarity in bipolar disorder: Correlation with burden of illness and moderation of treatment outcome. Journal of Psychiatric Research, 140, 205-213. doi: 10.1016/j.jpsychires.2021.05.082

Kesselring, I., Yaremych, H., Pegg, S., Dickey, L., & Kujawa, A. (2021). Zoom or in-person: An ecological momentary assessment study of time with friends and depressive symptoms on affect in emerging adults. Journal of Social and Clinical Psychology. Advance online publication. doi:10.1521/jscp.2021.40.2.97

Dickey, L., West, M., Pegg, S., Green, H., & Kujawa, A. (2021). Neurophysiological responses to interpersonal emotional images prospectively predict the impact of COVID-19 pandemic-related stress on internalizing symptoms. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, S2451-9022(21)00081-1. Advance online publication. doi: 10.1016/j.bpsc.2021.03.004

Pegg, S.*, Jeong, H. J.*, Foti, D., & Kujawa, A. (2021). Differentiating stages of reward responsiveness: Neurophysiological measures and associations with facets of the behavioral activation system. Psychophysiology, e13764. Advance online publication. doi: 10.1111/psyp.13764 *Joint first authorship

Pegg, S., Arfer, K., & Kujawa, A. (2021). Altered reward responsiveness and depressive symptoms: An examination of social and monetary reward domains and interactions with rejection sensitivity. Journal of Affective Disorders, 282, 717-725. doi: 10.1016/j.jad.2020.12.093

Sylvia, L. G., Janos, J. A., Pegg, S., Montana, R. E., Gold, A. K., Bianchi, M., & Nierenberg, A. A. (2021). Pilot study of a brief sleep intervention for suicidal ideation in bipolar disorder. Journal of Psychiatric Practice, 27, 109-114.

Weinberg, A., Ethridge, P., Pegg, S., Freeman, C., Kujawa, A., & Dirks, M. (2020). Neural responses to social acceptance predict behavioral adjustments following peer feedback in the context of a real-time social interaction task. Psychophysiology, e13748. Advance online publication. doi: 10.1111/psyp.13748

Kujawa, A., Green, H., Compas, B. E., Dickey, L., & Pegg, S. (2020). Exposure to COVID-19 pandemic stress: Associations with depression and anxiety in emerging adults in the United States. Depression and Anxiety, 37, 1280-1288.doi: 10.1002/da.23109

Nyman, T., Pegg, S., Kiel, E. J., Mistry-Patel, s., Schmall, L. J., & Brooker, R. J. (2020). Perceived social support moderates neural reactivity to emotionally valenced stimuli during pregnancy. Psychophysiology. doi: 10.1111/psyp.13647

Kujawa, A., Klein, D. N., Pegg, S., & Weinberg, A. (2020). Developmental trajectories to reduced activation of positive valence systems: A review of biological and environmental contributions. Developmental Cognitive Neuroscience, 43, 1-20. doi:10.1016/j.dcn.2020.100791

Pegg, S., Dickey, L., Green, H., & Kujawa, A. (2020). Differentiating clinically depressed adolescents with and without active suicidality: An examination of neurophysiological and self-report measures of reward responsiveness. Depression and Anxiety. Advance online publication. doi: 10.1002/da.23012 *Won Barbara Strudler Wallston Memorial Award

Pegg, S., & Kujawa, A. (2020). The effects of a brief motivation manipulation on reward responsiveness: A multi-method study with implications for depression. International Journal of Psychophysiology, 150, 100-107. doi: 10.1016/j.ijpsycho.2020.02.004

Pegg, S., Walsh, L. M., Becker-Haimes, E. M., Ramirez, V., & Jensen-Doss, A. (2019). Money makes the world go ‘round: A qualitative examination of the role funding plays in large-scale implementation and sustainment of youth evidence-based practice. Psychological Services. Advance online publication. doi: 10.1037/ser0000399

Pegg, S.*, Dickey, L.*, Mumper, E., Kessel, E., Klein, D. N., & Kujawa, A. (2019). Stability and change in emotional processing across development: A 6-year longitudinal investigation using event-related potentials. Psychophysiology, e13438. doi: 10.1111/psyp.13438 *Joint first authorship

Pegg, S., Ethridge, P., Shields, G. S., Slavich, G. M., Weinberg, A., & Kujawa, A. (2019). Blunted social reward responsiveness moderates the effect of lifetime social stress exposure on depressive symptoms. Frontiers in Behavioral Neuroscience, 13, 1-12. doi: 10.3389/fnbeh.2019.00178

Sylvia, L. G., Pegg, S., Dufour, S. C., Janos, J. A., Bernstein, E. E., Chang, W. C., Hall, N., Ellard, K. K., Nierenberg, A. A., & Deckersbach, T. (2019). Pilot study of a lifestyle intervention for bipolar disorder: Nutrition Exercise Wellness Treatment (NEW Tx). Journal of Affective Disorders, 250, 278-283. doi: 10.1016/j.jad.2019.03.033

Sylvia, L. G., Janos, J. A., Pegg, S., Dufour, S. C., Chang, W. C., Bernstein, E. E., Davis, B. J., Ellard, K. K., Deckersbach, T., & Nierenberg, A. A. (2019). Feasibility and acceptability of a lifestyle intervention for individuals with bipolar disorder. Journal of Psychiatric Practice, 25, 451-460. doi: 10.1097/PRA.0000000000000426

Caldieraro, M. A., Dufour, S. C., Sylvia, L. G., Gao, K., Ketter, T. A., Bobo, W. V., Walsh, S., Janos, J. A., Tohen, M., Reilly-Harrington, N. A., McElroy, S. L., Shelton, R. C., Bowden, C. L., Deckersbach, T., & Nierenberg, A. A. (2018). Treatment outcomes of acute bipolar depressive episode with psychosis. Depression and Anxiety, 35, 402-410. doi: 10.1002/da.22716

Uebelacker, L. A., Dufour, S. C., Dinerman, J. G., Walsh, S., Hearing, C. M., Gillette, L. T., Deckersbach, T., Nierenberg, A. A., Weinstock, L. M., & Sylvia, L. G. (2018). Examining the feasibility and acceptability of an online yoga class for mood disorders: A MoodNetwork study. Journal of Psychiatric Practice, 24, 60-67. doi: 10.1097/PRA.0000000000000286

Sylvia, L. G., Hearing, C. M., Montana, R. E., Gold, A. K., Walsh, S., Janos, J. A., Tovey, R. E., Deckersbach, T., & Nierenberg, A. A. (2018). MoodNetwork: An innovative approach to patient-centered research. Medical Care, 56, S48-S52. doi: 10.1097/MLR.0000000000000789

Caldieraro, M. A., Sylvia, L. G., Dufour, S. C., Walsh, S., Janos, J., Rabideau, D. J., Kamali, M., McInnis, M. G., Bobo, W. V., Friedman, E. S., Gao, K., Tohen, M., Reilly-Harrington, N. A., Ketter, T. A., Calabrese, J. R., McElroy, S. L., Thase, M. E., Shelton, R. C., Bowden, C. L., Kocsis, J. H., Deckersbach, T., & Nierenberg, A. A. (2017). Clinical correlates of acute bipolar depressive episode with psychosis. Journal of Affective Disorders, 217, 29-33. doi: 10.1016/j.jad.2017.03.059

Caldieraro, M. A., Walsh, S., Deckersbach, T., Bobo, W. V., Gao, K., Ketter, T. A., Shelton, R. C., Reilly-Harrington, N. A., Tohen, M., Calabrese, J. R., Thase, M. E., Kocsis, J. H., Sylvia, L. G., & Nierenberg, A. A. (2017). Decreased activation and subsyndromal manic symptoms predict lower remission rates in bipolar depression. Australian and New Zealand Journal of Psychiatry, 52, 994-1002. doi: 10.1177/0004867417741982

Jensen-Doss, A., Smith, A. M., Becker-Haimes, E. M., Ringle, V., Walsh, L. M., Nanda, M. M., Walsh, S., Maxwell, C. A., & Lyon, A. R. (2017). Individualized progress measures are more acceptable to clinicians than standardized measures: Results of a national survey. Administration and Policy in Mental Health and Mental Health Services Research, 45, 392-403. doi: 10.1007/s10488-017-0833-y

Selected Conference Poster Presentations

Pegg, S., Cárdenas, E, Humphreys, K. L., & Kujawa, A. (2023, September). Changes in neurophysiological responses to reward across peripartum and associations with depression. Poster accepted for presentation at the annual meeting of the Society for Research in Psychopathology, St. Louis, MO.

Pegg, S., Dickey, L., Dao, A., Arfer, K. B., & Kujawa, A. (2022, September). Social reward responsiveness moderates the effect of chronic stress on depressive symptoms in adolescents. Poster presented at the annual meeting of the Society for Research in Psychopathology, Philadelphia, PA.

Pegg, S., Cárdenas, E., Humphreys, K. L., & Kujawa, A. (2021, September). The effects of neural reward responsiveness and sleep disruption on peripartum depressive symptoms. Poster presented at the annual meeting of the Society for Research in Psychopathology (held virtually). *Smadar Levin Award finalist

Pegg, S., & Kujawa, A. (2020, June – September). Reward responsiveness enhanced by a brief motivation manipulation: A multi-method study with implications for depression. Poster presented at the APS Poster Showcase.

Pegg, S., Arfer, K. B., & Kujawa, A. (2020, March). Blunted neural responsiveness to social reward moderates the association between rejection sensitivity and depressive symptoms. Poster accepted for presentation at the 40th annual meeting of the Anxiety and Depression Association of American, San Antonio, TX. (Conference canceled)

Pegg, S., Dickey, L., Mumper, E., Kessel, E. M., Klein, D. N., & Kujawa, A. (2019, November). Developmental trajectories of earlier and later stages of emotional processing: A 6-year longitudinal investigation using event-related potentials. Poster presented at the Developmental Affective Neuroscience Symposium, Pittsburgh, PA.

Pegg, S. L., Arfer, K. B., & Kujawa, A. (2019, September). Neurophysiological measures of social feedback processing predict real-world experience of emotions in social settings. Poster presented at the 33rd annual meeting of the Society for Research in Psychopathology, Buffalo, NY.

Pegg, S. L., Dickey, L., Mumper, E., Kessel, E. M., Klein, D. N., & Kujawa, A. (2019, November). Developmental trajectories of earlier and later stages of emotional processing: A 6-year longitudinal investigation using event-related potentials. Poster presented at the Developmental Affective Neuroscience Symposium, Pittsburgh, PA.

Pegg, S. L., Arfer, K. B., & Kujawa, A. (2019, March) Distinct dimensions of mood symptoms associated with altered social reward processing in clinically depressed adolescents. Poster presented at the 39th annual meeting of the Anxiety and Depression Association of America, Chicago, IL.

Pegg, S. L., Ethridge, P., Shields, G. S., Slavich, G. M., Weinberg, A., & Kujawa, A. (2018, September). Associations between lifetime stress exposure and neurophysiological and behavioral measures of social feedback processing in emerging adults. Poster presented at the 32nd annual meeting of the Society for Research in Psychopathology, Indianapolis, IN.

Selected Conference Symposia

Pegg, S., Dickey, L., Dao, A., & Kujawa, A. (2023, May). Pathways to depression: Neural social and monetary reward responsiveness as moderators of the association between stress and depression in adolescents. Paper presented at the annual meeting of the Association for Psychological Science, Washington, DC.

Pegg, S., Zhang, H., Dickey, L., Dao, A., Arfer, K. B., & Kujawa, A. (2023, March). Reduced reward responsiveness moderates the association between chronic stress and depressive symptoms in adolescents. Paper presented at the biennial meeting of the Society for Research in Child Development, Salt Lake City, UT.

Pegg, S., & Kujawa, A. (2021, October). Neurophysiological response to reward and suicidality in adolescents. In G. Hajcak & T. Joiner (Chairs), Suicidal thoughts, behaviors, and their relationship to neural functions. Symposium presented at the annual meeting of the Society for Psychophysiological Research (held virtually).

Kujawa, A., Pegg, S., & Green, H. (2020, November). Social and monetary reward responsiveness as predictors of response to cognitive behavior therapy for adolescent depression. In A. Kujawa (Chair), Innovative approaches for advancing research on treatment and prevention of mood disorders. Symposium presented at the 54th annual meeting of the Association for Behavioral and Cognitive Therapies (held virtually).

Weinberg, A., Ethridge, P., Freeman, C., Pegg, S. L., Dirks, M. A., & Kujawa, A. (2019, September). With friends like these: Neural responses to peer feedback in depression and risk for depression. In G. Hajcak & J. Klawohn (Chairs), Depression and blunted neural response to reward: increasing specificity and prospective associations. Symposium presented at the 59th annual meeting of the Society of Psychophysiological Research, Washington, DC.

Kujawa, A., Pegg, S. L., Arfer, K., Finsaas, M., Kessel, E. M., Mumper, E., & Klein, D. N. (2019, September). Neural reactivity to social feedback and peer stress in adolescents at risk for depression. In S. Wilson & T. Olino (Chairs), Neurobehavioral indicators of risk for the development and familial transmission of internalizing, externalizing, and psychotic psychopathology. Symposium presented at the 33rd annual meeting of the Society for Research in Psychopathology, Buffalo, NY.


Honors

Grant Support:

Vanderbilt Institute for Clinical and Translational Research (VICTR). VR64881, Role: Principal Investigator, 2023-2024. 

Ruth L. Kirschstein Predoctoral Individual National Research Service Award (NRSA). F31 MH127817, National Institute of Mental Health, Role: Principal Investigator, 2021-2024.

Ruth L. Kirschstein Institutional National Research Service Award (NRSA)T32 MH018921, National Institute of Mental Health, Role: Predoctoral Trainee, 2020-2021. 

Russell G. Hamilton Graduate Leadership Institute Professional Developmennt and Training Grant, 2021.

Awards & Honors:

President's Award. Society for Research in Psychopathology, 2023.

Julius Seeman Award. Vanderbilt University, 2022.

SSCP Outstanding Student Researcher Award. Society for a Science of Clinical Psychology, 2021.

Smadar Levin Award Finalist. Society for Research in Psychopathology, 2021.

Sidney P. Colowick Graduate Scholarship Award. Vanderbilt University, 2021.

Harold Stirling Vanderbilt Graduate Scholarship Award. Vanderbilt University, 2021. 

Barbara Strudler Wallston Memorial AwardVanderbilt University, 2020.

University of Michigan Training Course in fMRI. NIH-funded participant, 2019.

Russell G. Hamilton Scholar. Vanderbilt University, 2018. 

Outstanding Senior Award. University of Miami, 2016. 

Phi Beta Kappa. University of Miami, 2016.