publications
(all are available upon EMAIL request)
Journal articles:
Chintapalli, R.T.V., and J.F. Hillyer. 2016. Hemolymph circulation in insect flight appendages: physiology of the wing heart and circulatory flow in the wings of the mosquito Anopheles gambiae. Journal of Experimental Biology. 219: 3945-3951. (PMID: 27742896) (See it in JEB) (Email me for a pdf copy)
Hillyer, J.F. 2016. In memoriam: George V. Hillyer (1943-2015). Journal of Parasitology. 102(6):659-661. (PMID 27553686) (See it in JP) (See it in BioOne)
League, G.P., and J.F. Hillyer. 2016. Integration of the circulatory, immune, and respiratory systems in mosquito larvae: immunity in the hemocyte-rich tracheal tufts. BMC Biology. 14:78. (PMID 27643786) (See it for FREE in BMC Biol)
Suggs, J.M., T.H. Jones, S.C. Murphree, and J.F. Hillyer. 2016. CCAP and FMRFamide-like peptides accelerate the contraction rate of the antennal accessory pulsatile organs (auxiliary hearts) of mosquitoes. Journal of Experimental Biology. 219(15): 2388-2395. (PMID: 27247317) (See it in JEB) (Email me for a pdf copy)
Hillyer, J.F. 2016. Insect immunology and hematopoiesis. Developmental and Comparative Immunology. 58:102-118. (PMID: 26695127) (See it in DCI) (Email me for a pdf copy)
Sigle, L.T. and J.F. Hillyer. 2016. Mosquito hemocytes preferentially aggregate and phagocytose pathogens in the periostial regions of the heart that experience the most hemolymph flow. Developmental and Comparative Immunology. 55:90-101. (PMID 26526332) (See it in DCI) (Email me for a pdf copy)
Hillyer, J.F. 2015. Acceptance of the 2015 Henry Baldwin Ward Medal: My journey in parasitology, and with parasitologists. Journal of Parasitology. 101(6):623-626 (PMID: 26335281) (See it in JP) (Email me for a pdf copy)
Hillyer, J.F., T.Y. Estevez-Lao, and H.E. Mirzai. 2015. The neurotransmitters serotonin and glutamate accelerate the heart rate of the mosquito Anopheles gambiae. Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology. 188:49-57. (Pubmed) (See it in CBP-A) (Email me for a pdf copy)
Hillyer, J.F. 2015. Integrated immune and cardiovascular function in Pancrustacea: Lessons from the insects. Integrative & Comparative Biology. DOI: 10.1093/icb/icv021
(Pubmed) (See it in ICB) (Email me for a pdf copy)
Ellison, H.E., T.Y. Estévez-Lao, C.S. Murphree, and J.F. Hillyer. 2015. Deprivation of both sucrose and water reduces the mosquito heart contraction rate while increasing the expression of nitric oxide synthase. Journal of Insect Physiology. 74:1-9.
(PubMed) (See it in JIP) (Email me for a pdf copy)
League, G.P., O.C. Onuh and J.F. Hillyer. 2015. Comparative structural and functional analysis of the larval and adult dorsal vessel and its role in hemolymph circulation in the mosquito Anopheles gambiae. Journal of Experimental Biology. 218:370-80.
(PubMed) (See it in JEB) (Email me for a pdf copy)
Kong, L., A. Lu, J. Guan, B. Yang, M. Li, J.F. Hillyer, N. Ramarao, K. Söderhäll, C. Liu, and E. Ling. 2015. Thermolysin damages animal life through degradation of plasma proteins enhanced by rapid cleavage of serpins and activation of proteases. Archives of Insect Biochemistry and Physiology. 88(1):64-84
(PubMed) (See it in AIBP) (Email me for a pdf copy)
Hillyer, J.F. 2014. Editorial overview: Vectors and medical and veterinary entomology: Immune responses to pathogen infections in insect vectors. Current Opinion in Insect Science. 3:v-vii
(See it in COIS) (Email me for a pdf copy)
Hillyer, J.F., and M.R. Strand. 2014. Mosquito hemocyte-mediated immune responses. Current Opinion in Insect Science. 3:14-21
(PubMed) (See it in COIS) (Email me for a pdf copy)
Boppana, S., and J.F. Hillyer. 2014. Hemolymph circulation in insect sensory appendages: functional mechanics of antennal accessory pulsatile organs (auxiliary hearts) in the mosquito Anopheles gambiae. Journal of Experimental Biology. 217(17):3006-3014.
(PubMed) (See it in JEB) (Email me for a pdf copy)
Raphemot, R., T.Y. Estévez-Lao, M.F. Rouhier, P.M. Piermarini, J.S. Denton, and J.F. Hillyer. 2014. Molecular and functional characterization of Anopheles gambiae inward rectifier potassium (Kir1) channels: A novel role in egg production. Insect Biochemistry and Molecular Biology. 51:10-19.
(PubMed) (See it in IBMB) (Email me for a pdf copy)
Hillyer, J.F., T.Y. Estévez-Lao, and L.E. de la Parte. 2014. Myotropic effects of FMRFamide containing peptides on the heart of the mosquito Anopheles gambiae. General and Comparative Endocrinology. 202:15-25.
(Pubmed) (See it in GCE) (Email me for a pdf copy)
Lu, A., X. Li , J.F. Hillyer, B.T. Beerntsen, K. Söderhäll, and E. Ling. 2014. Recombinant Drosophila prophenoloxidase 1 is sequentially cleaved by α-chymotrypsin during in vitro activation. Biochimie. 102:154-165.
(Pubmed) (See it in Biochimie) (Email me for a pdf copy)
Estévez-Lao, T.Y, and J.F. Hillyer. 2014. Involvement of the Anopheles gambiae Nimrod gene family in mosquito immune responses. Insect Biochemistry and Molecular Biology. 44:12-22.
(Pubmed) (See it in IBMB) (Email me for a pdf copy)
Chen, W., and J.F. Hillyer. 2013. FlyNap (triethylamine) increases the heart rate of mosquitoes and eliminates the cardioacceleratory effect of the neuropeptide CCAP. PLoS ONE. 8(7): e70414.
(Pubmed) (Download Free from the PLOS ONE Website)
King, J.G., and J.F. Hillyer. 2013. Spatial and temporal in vivo analysis of circulating and sessile immune cells in mosquitoes: hemocyte mitosis following infection. BMC Biology. 11:55. (Pubmed) (Download Free from BMC Biology)
Xu, J., J.F. Hillyer, B. Coulibaly, M. Sacko, A. Dao, O. Niare, M.M. Riehle, S.F. Traoré, and K.D. Vernick. 2013. Wild Anopheles funestus mosquito genotypes are permissive for infection with the rodent malaria parasite, Plasmodium berghei. PLoS ONE. 8(4): e61181. (Pubmed) (Download Free from PLoS ONE)
Estévez-Lao, T.Y, D.S. Boyce, H.-W. Honegger, and J.F. Hillyer. 2013. Cardioacceleratory function of the neurohormone CCAP in the mosquito Anopheles gambiae. Journal of Experimental Biology. 216(4):601-613. (PubMed) (Article on JEB website) (Story in Inside JEB).
King, J.G., and J.F. Hillyer. 2012. Infection-induced interaction between the mosquito circulatory and immune systems. PLoS Pathogens. 8(11): e1003058. (Pubmed) (Download Free from PLoS Pathogens)
Murdock, C.C., K.P. Paaijmans, A.S. Bell, J.G. King, J.F. Hillyer, A.F. Read and M.B. Thomas. 2012. Complex effects of temperature on mosquito immune function. Proceedings of the Royal Society B: Biological Sciences. 279(1741):3357-3366. (Pubmed) (Download Free from Proc Biol Sci)
Hillyer, J.F., T.Y. Estévez-Lao, L.J. Funkhouser, and V.A. Aluoch. 2012. Anopheles gambiae Corazonin: gene structure, expression, and effect on mosquito heart physiology. Insect Molecular Biology. 21(3):343-355. (Pubmed) (Download from Insect Mol Biol)
Coggins, S.A., T.Y. Estévez-Lao, and J.F. Hillyer. 2012. Increased survivorship following bacterial infection by the mosquito Aedes aegypti as compared to Anopheles gambiae correlates with increased transcriptional induction of antimicrobial peptides. Developmental and Comparative Immunology. 37(3-4):390-401. (Pubmed) (Download from Dev Comp Immunol)
King, J.G., K.D. Vernick, and J.F. Hillyer. 2011. Members of the salivary gland surface protein family (SGS) are major immunogenic components of mosquito saliva. Journal of Biological Chemistry. 286(47):40824-40834. (Pubmed) (Download from JBC)
Honegger, H.-W., T.Y. Estévez-Lao, and J.F. Hillyer. 2011. Bursicon-expressing neurons undergo apoptosis after adult ecdysis in the mosquito Anopheles gambiae. Journal of Insect Physiology. 57(7):1017-1022. (Pubmed) (ScienceDirect)
Andereck, J.W., J.G. King, and J.F. Hillyer. 2010. Contraction of the ventral abdomen potentiates extracardiac retrograde hemolymph propulsion in the mosquito hemocoel. PLoS ONE. 5(9):e12943. (PubMed) (Download FREE from PLoS ONE)
Aliota, M.T., J.F. Fuchs, T.A. Rocheleau, A.K. Clark, J.F. Hillyer, C.C. Chen, and B.M. Christensen. 2010. Mosquito transcriptome profiles and filarial worm susceptibility in Armigeres subalbatus. PLoS Neglected Tropical Diseases. 4(4):e666. (PubMed) (Download FREE from PLoS NTDs)
Glenn, J.D., J.G. King, and J.F. Hillyer. 2010. Structural mechanics of the mosquito heart and its function in bidirectional hemolymph transport. Journal of Experimental Biology. 213(4):541-50. (PubMed) (Download FREE from JEB)
Hillyer, J.F., T. Estevez-Lao. 2010. Nitric oxide is an essential component of the hemocyte-mediated mosquito immune response against bacteria. Developmental and Comparative Immunology. 34(2):141-149. (PubMed) (ScienceDirect) (Request a FREE pdf)
Hillyer, J.F. 2009. Transcription in mosquito hemocytes in response to pathogen exposure. Journal of Biology. 8(5):51. (Invited Review) (PubMed) (Download FREE from JB)
Hillyer, J.F., C. Barreau, and K.D. Vernick. 2007. Efficiency of salivary gland invasion by malaria sporozoites is controlled by rapid sporozoite destruction in the mosquito haemocoel. International Journal for Parasitology. 37(6):673-81. (PubMed) (Download FREE from PMC)
Hillyer, J.F., and B.M. Christensen. 2005. Mosquito phenoloxidase and defensin colocalize in melanization innate immune responses. The Journal of Histochemistry & Cytochemistry 53(6):689-698. (PubMed) (Download free from JHC)
Wang, X., J.F. Fuchs, L-C Infanger, T.A. Rocheleau, J.F. Hillyer, C.C. Chen and B.M. Christensen. 2005. Mosquito innate immunity: involvement of beta 1,3-glucan recognition protein in melanotic encapsulation immune responses in Armigeres subalbatus. Molecular and Biochemical Parasitology 139(1):65-73. (PubMed)
Hillyer, J.F., S.L. Schmidt, J.F. Fuchs, J.P. Boyle, and B.M. Christensen. 2005. Age-associated mortality in immune challenged mosquitoes (Aedes aegypti) correlates with a decrease in haemocyte numbers. Cellular Microbiology 7(1):39-51. (PubMed)
Wang, X., T.A. Rocheleau, J.F. Fuchs, J.F. Hillyer, C.C. Chen, and B.M. Christensen. 2004. A novel lectin with a fibrinogen-like domain and its potential involvement in the innate immune response of Armigeres subalbatus against bacteria. Insect Molecular Biology 13(3):273-282. (PubMed)
Hillyer, J.F., S.L. Schmidt, and B.M. Christensen. 2004. The antibacterial innate immune response by the mosquito Aedes aegypti is mediated by hemocytes and independent of gram type and pathogenicity. Microbes and Infection 6(5):448-459. (PubMed)
Boyle, J.P., J.F. Hillyer, and T.P. Yoshino. 2003. Pharmacological and autoradiographical characterization of serotonin-like activity in sporocysts of the human blood fluke, Schistosoma mansoni. Journal of Comparative Physiology A-Neuroethology, Sensory, Neural, and Behavioral Physiology 189(8):631-641. (PubMed)
Hillyer, J.F., S.L. Schmidt, and B.M. Christensen. 2003. Hemocyte-mediated phagocytosis and melanization in the mosquito Armigeres subalbatus following immune challenge by bacteria. Cell & Tissue Research 313(1):117-127. (PubMed)
Johnson, J.K., T.A. Rocheleau, J.F. Hillyer, C.C. Chen, J. Li, and B.M. Christensen. 2003. A potential role for phenylalanine hydroxylase in mosquito immune responses. Insect Biochemistry and Molecular Biology 33(3):345-354. (PubMed)
Hillyer, J.F., S.L. Schmidt, and B.M. Christensen. 2003. Rapid phagocytosis and melanization of bacteria and Plasmodium sporozoites by hemocytes of the mosquito, Aedes aegypti. Journal of Parasitology 89(1):62-69. (PubMed)
Hillyer, J.F., and B.M. Christensen. 2002. Characterization of hemocytes from the yellow fever mosquito, Aedes aegypti. Histochemistry and Cell Biology 117(5):431-440. (PubMed)
Hillyer, J.F., and R.M. Albrecht. 2001. Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles. Journal of Pharmaceutical Sciences 90(12):1927-1936. (PubMed)
Smartt, C.T., L.M. Kiley, J.F. Hillyer, and B.M. Christensen. 2001. Aedes aegypti glutamine synthetase: expression and gene structure. Gene 274(1-2):35-45. (PubMed)
Zhao, X., C.T. Smartt, J.F. Hillyer, and B.M. Christensen. 2000. A novel member of the RING finger gene family asociated with reproductive tissues of the mosquito, Aedes aegypti. Insect Molecular Biology 9(3):301-308. (PubMed)
Hillyer, J.F., and R.M. Albrecht. 1998. Correlative instrumental neutron activation analysis, light microscopy, transmission electron microscopy, and X-ray microanalysis for qualitative and quantitative detection of colloidal gold spheres in biological specimens. Microscopy and Microanalysis 4(5):481-490. (PubMed)
book chapter:
Hillyer, J.F. 2010. Mosquito immunity. Invertebrate Immunity. 708:218-238.
(ISBN: 978-1-4419-8058-8)
