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Structural insights into base excision repair

May. 5, 2023—As the instruction manual of the cell, DNA plays an essential role in development and organism function. Consequently, several mechanisms exist to repair DNA following damage. Oxidants result in structural damage to DNA which are typically repaired via base excision repair (BER). A set of proteins called glycosylases serve to recognize these DNA lesions and...

Congratulations: Ben Brown & Alican Gulsevin

May. 5, 2023—Brown receives NIH funding Congratulations to Ben Brown, research assistant professor in the Meiler lab, on his recent NIH award for his project titled Developing a computational platform for induced-fit and chemogenetic drug design. The goal of the project is to integrate AI and physics-based molecular modeling methods to address longstanding challenges in modeling largescale...

Bill Riner sets sail on the trip of a lifetime

Apr. 21, 2023—Some days you might think to yourself, “I want to retire and sail around the world.” For Center for Structural Biology Sr. Systems Administrator Bill Riner, that day is coming sooner rather than later. On April 28, Bill officially retires from Vanderbilt University—and he’s sailing around the world! Bill signed up for the 2023-2024 Clipper...

Insights into the regulation of Huntingtin-associated proteins

Mar. 31, 2023—Huntington’s disease is a genetic neurodegenerative disease that causes wide-ranging issues with motor skills and cognitive abilities. The primary cause of the disease has been identified as mutations in the protein huntingtin (Htt). Htt interacts with over 200 other proteins and plays a role in cell signalling and trafficking. The Chazin group recently published an...

Protein Trafficking: An interactive network of coats, cargos and adaptors – Oh my!

Mar. 24, 2023—Come take a ride along the intracellular highways that are trafficking pathways! Cells use vesicles to transport diverse cargo, such as transmembrane proteins, between cellular compartments. In this complex system, membrane coat proteins work together with adaptor proteins to recruit cargo, encase them within vesicles and deliver them to the proper destination. These coat proteins...

Sanders promoted to Vice Dean of Basic Sciences

Mar. 17, 2023—Chuck Sanders was recently promoted from associate dean for research to vice dean of the Vanderbilt School of Medicine Basic Sciences by new Dean John Kuriyan. Chuck will continue in the responsibilities that he had been fulfilling for five years as associate dean for research, which include monitoring IT infrastructure and working closely with Vanderbilt...

MBTP/CSB Student Feedback Meeting moved to March 14

Mar. 6, 2023—Molecular Biophysics Training Program (MBTP) Director Walter Chazin will sit down with students to gather feedback on the training program and seminar series. The meeting has been moved Tuesday, March 14, at 12:20pm in 1220 MRB3. A limited number of box lunches will be available. This meeting is for ALL STUDENTS in MBTP and CSB...

CSB co-hosts Discovery Lecture Series speaker

Mar. 6, 2023—The Department of Biochemistry and the CSB will host Dr. Yifan Cheng, University of California San Francisco (UCSF), as The Discovery Lecture Series speaker on Thursday, March 9, at 4pm in 208 Light Hall. Dr. Cheng is an investigator of the Howard Hughes Medical Institute (HHMI) and professor of biochemistry and biophysics at UCSF. His...

MBTP student feedback meeting scheduled for March 7

Feb. 17, 2023—Molecular Biophysics Training Program (MBTP) Director Walter Chazin will sit down with students to gather feedback on the training program and seminar series. The meeting is scheduled for the regular seminar time slot on Tuesday, March 7, at 12:20pm in 1220 MRB3. This meeting is for ALL students in MBTP Labs and is for students...

**CSB Research: Tilting retromer to improve the model**

Jan. 13, 2023—Does your protein of interest show favored orientations in cryo-EM? Or perhaps one specific region is poorly resolved relative to another? If so, consider looking into this recent publication from Amy Kendall, Mintu Chandra, Will Wan and Lauren Jackson. Their findings, published in the Journal of Biological Chemistry, report an improved model of the retromer...

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