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2024 Karpay Award: Call for applications

Sep. 20, 2023—The Karpay Award Committee is now soliciting applications for the 2024 Karpay Award in Structural Biology. This award was established in 2010 to commemorate Dr. Anne Karpay, whose studies were focused on membrane protein structural biology under the guidance of Professors Chuck Sanders and Tina Iverson. Dr. Karpay’s career ended prematurely following a 4-year battle...

On the origins of pentose sugars in everninomicin D biosynthesis

Sep. 20, 2023—Everninomicins are a family of naturally produced oligosaccharides, some of which exhibit ribosome-targeting antibiotic activity. Everninomicin A (EVA) was developed into late-phase clinical trials as an antibiotic but eventually pulled due to toxicity concerns. Toxicity was attributed to aggregates in the formulations, likely caused by π-stacking interactions from flanking aromatic rings in EVA. Current research...

CSB researchers receive funding for novel research

Sep. 20, 2023—The American Society for Cell Biology (ASCB) recently announced the formation of Peer Imaging Clusters (PIC) to receive collaborative research grants to pursue novel research projects as part of the PAIR-UP Imaging Science program for Black imaging scientists. Jamaine Davis leads a PIC that includes fellow CSB researcher Steven Damo, Vanderbilt assistant professor and researcher...

MOE training sessions set for August, September & October

Aug. 11, 2023—Molecular Operating Environment (MOE) software users can participate in training sessions for small molecule virtual screening, fragment-based drug design and peptide modeling, conformational searching and docking over the next three months. Mauricio Rodriguez, of Chemical Computing Group, will lead the training sessions via Zoom. MOE enables a wide range of molecular modeling methods inside a...

Clicking into place with paramagnetic NMR restraints

Jul. 14, 2023—Nuclear magnetic resonance (NMR) is an incredibly powerful technique for determining protein structure. A complete dataset of chemical shifts (CS) and nuclear Overhauser effects (NOEs) obtained from NMR can be used to determine structural models of a protein of interest. In the case of integral membrane proteins, however, there is a lot of difficulty in...

CSB Spotlight: Yang Lab

Jul. 6, 2023—John Yang, assistant professor of chemistry, joined the Vanderbilt University in the fall of 2020. He forged his path to Vanderbilt via Nankai University in China, UCLA and MIT with research focusing on theoretical and computational chemistry, chemical biology, physical organic chemistry and enzyme catalysis. John joined the CSB not long after arriving at Vanderbilt,...

Jackson named 2023 Chancellor Faculty Fellow

Jun. 12, 2023—Congratulations to Lauren Jackson, associate professor of biological sciences, on being selected to the 2023 cohort of Chancellor Faculty Fellows along with twelve other recently tenured faculty. The fellows are composed of highly accomplished teachers and researchers from a wide variety of disciplines and areas of expertise. Lauren was chosen for her work to uncover...

Structural plasticity in bacterial flagellar motors

Jun. 12, 2023—Chemotaxis is the process of moving in response to one’s environment, and in bacteria, this process is supported largely by flagella. The flagellum is a motility organelle comprised of an elongated filament and various rings, consistent with its role as a rotary motor. One component, the MS-ring, is vital, both for the assembly and rotation...

CSB to co-sponsor Apex Lecture on May 22

May. 12, 2023—The Vanderbilt School of Medicine Basic Sciences is launching the Apex Lecture Series to recognize scientists who are at the forefront of sea-change advances in biomedical discovery. The seminars will connect Vanderbilt’s campus scientific community with scientists who are pioneering new fields, new ideas and new opportunities to benefit human health. The CSB will co-sponsor...

MOE workshop scheduled for structure-based drug design

May. 12, 2023—In collaboration with the Lee, Mchaourab and Carrasco labs, the CSB is upgrading from four seats of the Molecular Operating Environment (MOE) to a site license that offers unlimited tokens. MOE enables a wide range of molecular modeling methods inside a modern and well-organized GUI. These include, but are not limited to, structure- and ligand-based...

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