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Teasing out a role for tepsin in AP-4 mediated trafficking

May. 21, 2024—AP-4 is one complex in a family of coat proteins that mediate vesicle formation at various membranes. Previous work has determined that AP-4 is recruited specifically to the trans-Golgi network, but the exact mechanisms governing AP-4 vesicle budding or distribution are still poorly understood. Further, loss of the AP-4 complex in humans results in a...

Vanderbilt Phenocam goes live

May. 21, 2024—The Phenocam at Vanderbilt monitors changes in tree canopy greenness and updates at thirty-minute intervals. The footage will provide researchers in the Department of Earth and Environmental Sciences with permanent continuous data on the vegetation dynamics on campus under climate change. The Vanderbilt site is part of the PhenoCam Network, a cooperative network of more than...

Vanderbilt launches sustainable lab program

May. 21, 2024—Did you know that laboratory spaces traditionally consume about five times more energy per square foot than standard office spaces? In an effort to help reduce the environmental impact of lab activities, Vanderbilt has launched the Vanderbilt Sustainable Labs program. VSL is an initiative from Environmental Health, Safety and Sustainability in the Division of Administration...

Iverson Lab provides new insights on chemotaxis

May. 3, 2024—The lab of Tina Iverson, Louise B. McGavock Professor and professor of pharmacology, in collaboration with researchers at the University of California, San Francisco; Stanford University; and The Weizmann Institute of Science in Israel have published new work in Nature Microbiology, providing new insights on chemotaxis. Chemotaxis is a key characteristic shared by all infectious...

Chazin to lead biomedical research education and training

Apr. 9, 2024—Congratulations to Walter Chazin, founder and former director of the Center of Structural Biology, on being named senior associate dean of BRET! Walter takes over from Kathleen Gould, who steps down after 14 years of leading the BRET Office to return her focus to her research program. Read the full announcement on the Basic Sciences...

Illuminating a critical step in DNA replication

Mar. 22, 2024—Brandt Eichman (Biological Sciences) and Walter Chazin (Biochemistry and Chemistry) recently visualized a multi-functional protein in action using the state-of-the-art CSB Cryo-EM Facility. The findings, recently published in Nature Structural & Molecular Biology, shed light on how DNA replication is initiated in humans. Read their reflections on this critical research in this Q&A with the...

Vanderbilt Travel hosting on-site Global Entry enrollment event, April 15-17, 2024

Feb. 22, 2024—Vanderbilt Travel is hosting a Global Entry enrollment event with U.S. Customs and Border Patrol April 15-17, 2024, and will be holding on-site interviews at Vanderbilt Finance, located in the Baker Building, Suite 900, for Vanderbilt travelers and immediate family members who travel internationally and have been conditionally approved. What is Global Entry? Global...

CryoEM facility offers office hours

Feb. 21, 2024—The CryoEM team has set up office hours on Wednesdays from 2pm to 3pm in 003 ESB. The team—Melissa Chambers, Scott Collier, Mariam Haider—is available to assist users with CryoSPARC data processing, general EM data processing, sample prep, microscope operation, etc. If you can’t make it to the Engineering Science Building, email any staff member...

CSB Core Update

Feb. 21, 2024—The Biophysical Instrumentation Core and the Megalab Core have been combined to form the new Vanderbilt Center for Structural Biology Labs and Instrumentation Facility. The facility supports mass photometry, biolayer interferometry, stopped-flow spectrometry, microscale thermophoresis, dynamic light scattering, circular dichroism and microcalorimetry instruments for measuring macromolecular conformation, stability and binding interactions. The facility also provides...

Enzyme substrate positioning dynamics: To be electrostatic or not to be?

Feb. 9, 2024—Bioengineered enzymes are used in a wide variety of applications including chemical synthesis, waste degradation, fuel production, disease diagnosis and treatment. The development of efficient enzymes can be accelerated by understanding the catalytic origin of enzymes, a fundamental question in the field of chemistry. Catalysis is believed to rely largely on protein dynamics, one facet...

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