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Jenny Tran presents Karpay Award Seminar January 21

Jan. 17, 2025—2025 Anne Karpay Award in Structural Biology Winner Jenny Tran, of the Breann Brown lab, gives the MBTP/CSB Seminar on Tuesday, January 21, at 12:20pm in 1220 MRB3. Although in high school Jenny completed a summer research internship with Howard Hughes Medical Institute Professor David Lynn at Emory University, she originally wanted to pursue architecture...

CSB Research Faculty Profile: Heather Kroh

Jan. 9, 2025—Heather Kroh, PhD, is a research assistant professor in the Pathology, Microbiology and Immunology department and currently works in the Lacy lab. With a long-standing dedication to scientific education, she participates in many mentoring and outreach programs, but her favorite activity might just be picking up pretty rocks. Meet Heather … What project are you...

A preprocessing package tailored to individual needs

Jan. 3, 2025—Cryo-electron tomography (cryo-ET) is method for determining structure that relies on tilting a microscope sample stage to collect a wide range of sample views. This unique acquisition technique is especially useful for imaging in the context of cells or intact extracellular particles, allowing researchers to study structure in a near-native environment. Subtomogram averaging (STA), a...

Unmasking antagonists: a deep dive into the structural binding poses of PPARγ ligands

Dec. 13, 2024—Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-regulated transcription factor located in the nucleus. Endogenous ligands, such as lipids and fatty acids, bind an orthosteric pocket in the ligand-binding domain (LBD) of PPARγ and function as agonists to activate gene expression related to adipogenesis and insulin sensitization. Synthetic small molecule ligands, including FDA-approved antidiabetic drugs,...

CSB Research Spotlight: Mchaourab Lab – Describing conformational landscapes of cell membrane transporters

Dec. 6, 2024—PhD student Alexandra Schwartz and Professor Hassane Mchaourab (Molecular Physiology and Biophysics, Center for Applied Artificial Intelligence in Protein Dynamics) developed a methodological blueprint to describe the structure of cell membrane transporters. Read more to learn how the Spectroscopy and AI method provide a unique window into protein structure and a mechanism of action. Morphing...

CSB Research Spotlight: Ren Lab – Understanding mRNA export

Dec. 5, 2024—A newly determined structure from the lab of Yi Ren reveals information about the mRNA export pathway and suggests that herpes viruses could hijack that interaction to infect their host. The new structures also reveal how certain mutations in the protein complex could play a role in cancers. First author Bradley Clarke and coauthors describe...

Looking in All Directions: Exploring a New Horizon for PCOS Therapeutics

Nov. 14, 2024—This article was originally published in The Protein Society’s November 2024 Under the Microscope newsletter. It is published here by permission of The Protein Society and the author. By Kathryn R. Brewer, PhD Candidate in Biochemistry, Sanders Lab A 20-year-old woman waits to see her gynecologist. For years she has been experiencing troubling symptoms —...

MOE November Software Training

Nov. 12, 2024—Molecular Operating Environment (MOE) software users can participate in training sessions focused on Antibody Modeling and Protein Engineering applications. The sessions are held at various dates throughout November and cover topics, including, protein engineering and properties, developability, hot spot analysis, antibody modeling, humanization and molecular surfaces. Mauricio Rodriguez, of Chemical Computing Group, will lead the...

Unlocking the Secrets of Protein Folding

Oct. 18, 2024—It’s often the simplest and most informal of invitations that can open a world of endless possibilities and lifelong relationships. That’s how Professor Jens Meiler’s extraordinary scientific journey began in the lab of Nobel Prize winner David Baker. What has he made of the opportunities presented to him that day? Here is his story. ...

Meiler lab receives funding to advance vaccine research against alphaviruses

Oct. 11, 2024—The Meiler lab is leading a multi-institution team that was awarded up to $46 million in funding to drive groundbreaking vaccine research from ARPA-H‘s Antigens Predicted for Broad Viral Efficacy through Computational Experimentation (APECx) program. The funding will support a consortium of 14 principal investigators (PIs) across eight institutions, enabling a collaborative effort to push...

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