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Advancing Lipidomics

High Confidence Lipidomics via a Lipid Structure Atlas Enables the CIT to Predict Dysregulation

Lipids play an important role in health and disease, such as de novo lipid synthesis in cancer cell growth and survival or dysregulation of lipid metabolism in neurodegenerative diseases. Yet lipidomics research, the study of lipid species, pathways and their interactions with other metabolites inside an organism, is considered an emerging discipline. To advance the field, high-precision ion mobility-mass spectrometry resources in the CIT were utilized to develop a conformational database for lipids.

The atlas includes collision cross section information for numerous lipid classes, including: sphingomyelin, cerebroside, ceramide, phosphatidylethanolamine, phosphatidylcholine, phosphatidylserine, and phosphatidic acid. The figure below outlines the important correlations that were discovered for glycerophospholipids (PS) and sphingolipids (GlcCer). This lipid atlas is available in the CIT to help collaborators better understand the role of lipids in their specific disease.

Katrina Leaptrot, Post Doc in the McLean Lab

Read the publication: https://www.ncbi.nlm.nih.gov/pubmed/30816114
Read the Vanderbilt News article: https://news.vanderbilt.edu/2019/02/28/new-lipid-shape-atlas-holds-key-to-early-disease-detection/
Read the Vanderbilt Institute of Chemical Biology’s summary article: https://www.vanderbilt.edu/vicb/discovery_featured3.html

Go to the publication

Lipid Shape Atlas

Read more…

Collision Cross Section Data

A Guide to Metabolite Annotation: A Mini-Series (Part II)

June 15, 2020

Metabolite Annotations

A Guide to Metabolite Annotation: A Mini-Series

June 8, 2020

Small Molecule Omics and Cancer Biology

January 14, 2020

The Human Microbiome’s Metabolome

July 31, 2019

Katrina Leaptrot, Post Doc in the McLean Lab

Advancing Lipidomics

April 17, 2019

Large Metabolomics Studies

Liquid Handling Platform Added for Large Metabolomics Studies

February 28, 2019

Quantity of Identified Metabolites in Untargeted Experiments

February 21, 2019

Metabolic Quenching

January 21, 2019

High-Throughput Multi-Omic Analyses

High-Throughput Multi-Omic Analyses

January 21, 2019

qualitative amino acid panel

Qualitative Amino Acid Panel

January 21, 2019

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Liquid Handling Platform Added for Large Metabolomics Studies The Human Microbiome’s Metabolome