Multi-disciplinary collaboration across campus:
An Integrated, High-Throughput Strategy for Multi-Omic Analyses
In collaboration with the Vanderbilt DARPA RTA Team (R. Caprioli, E. Skaar, J. Wikswo, J. McLean, B. Lacey, J. Norris), the CIT has contributed to developing an automated multi-omic sample preparation approach. The approach, sample preparation for multi-omics technologies (SPOT), provides equivalent performance to typical individual omic preparation methods but greatly enhances throughput and minimizes the resources required for multiomic experiments. In this manuscript, SPOT was used to understand the mechanism of action of Zn-treated HL-60 cells using transcriptomic, proteomic and metabolomic data generated from a common cell culture sample.
The details are available in the Journal of Proteome Research:
https://pubs.acs.org/doi/pdf/10.1021/acs.jproteome.8b00302
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allwarv2020-06-15 07:37:092020-06-08 07:45:01A Guide to Metabolite Annotation: A Mini-Series (Part II)
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allwarv2020-06-08 07:33:402020-06-08 07:34:40A Guide to Metabolite Annotation: A Mini-Series
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allwarv2020-01-14 15:07:102020-01-14 15:52:20Small Molecule Omics and Cancer Biology
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allwarv2019-07-31 08:58:202019-07-31 09:07:42The Human Microbiome’s Metabolome
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allwarv2019-04-17 12:16:102019-04-17 12:39:16Advancing Lipidomics
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allwarv2019-02-28 13:14:582019-04-17 12:41:02Liquid Handling Platform Added for Large Metabolomics Studies
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allwarv2019-02-21 14:01:192019-04-17 12:42:31Quantity of Identified Metabolites in Untargeted Experiments
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allwarv2019-01-21 13:13:222019-04-17 12:44:31Metabolic Quenching
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allwarv2019-01-21 13:12:582019-04-17 12:45:55High-Throughput Multi-Omic Analyses
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allwarv2019-01-21 13:12:392019-04-17 12:47:30Qualitative Amino Acid Panel
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