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Researcher Bios
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R. Stephen Lloyd lloydst@ohsu.edu Bio R. Stephen Lloyd received his B.S. in Biology from Florida State University, and Ph.D. in molecular biology from The University of Texas Graduate School of Biomedical Sciences, M.D. Anderson Hospital and Tumor Institute, Houston under Charles Haidle. After postdoctoral training at Stanford University with Philip Hanawalt, he worked for the Genex Corporation and subsequently, has been a faculty member at Vanderbilt University, The University of Texas Medical Branch and Oregon Health & Science University. His research interests are in DNA repair, replication and mutagenesis. |
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Carmelo Rizzo c.rizzo@vanderbilt.edu Bio Carmelo Rizzo received his B. A. in Chemistry from Temple University (1984) and a Ph. D. in Organic Chemistry from the University of Pennsylvania (1990). He was an NIH Post-doctoral Research Associate at Columbia University before joining the faculty at Vanderbilt University in 1992. He currently holds the rank of Professor of Chemistry and Biochemistry. Dr. Rizzo has been an Investigator in the Center for Molecular Toxicology since 2001 and has served as Co-Deputy Director since 2003. He has alsos served as a member of the National Institute of Environmental Health Science Review Committee (2003-2007) and the Editorial Advisory Board of Chemical Research in Toxicology (2006-2008). Dr. Rizzo's research interests are center on the synthesis and study of oligonucleotides that are covalently modified by potential carcinogens. Of particular interest are genotoxins derived from lipid peroxidation such as acrolein, 4-hydroxynonenal, and malondialdehyde and heterocyclic amines found in cooked meats such as 2-amino-3-methylimidazo[4,5-f]quinoline (IQ). His laboratory has developed chemistry for the incorporation of these adducts into DNA in a sequence-specific manner. Once synthesized, the conformation, replication, and repair of the modified oligonucleotides are studied. A common theme of the research activities is to relate the structural perturbations caused by the DNA adduct to its biological processing. |
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Michael Stone michael.p.stone@vanderbilt.edu Bio Dr. Michael P. Stone has expertise in the area of DNA structure, perturbations to DNA structure induced by chemical mutagens, and the relationships between modifications to DNA structure and chemical mutagenesis. The primary experimental technique Dr. Stone utilizes to examine DNA structure is nuclear magnetic resonance (NMR). Dr. Stone received his Ph.D. from the University of California, Irvine, and completed post-doctoral research at the University of Rochester before coming to Vanderbilt. He has been at Vanderbilt University since 1984, where he is currently Professor of Chemistry. |
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Martin Egli martin.egli@vanderbilt.edu Bio Dr. Martin Egli and associates use X-ray crystallography as their main tool to study the structures of nucleic acids, proteins and their complexes. On-going efforts in his laboratory focus on (i) the structure and stability/activity of native and chemically modified nucleic acids and an etiology of nucleic acid structure, (ii) structural investigations of the interactions between Y-class DNA polymerases and various DNA adducts, and (iii) the structure and function of the cyanobacterial KaiABC circadian clock. Dr. Egli received his undergraduate and graduate degrees from the Swiss Federal Institute of Technology (ETH-Zürich). Following postdoctoral studies at MIT and faculty appointments at ETHZ and Northwestern University he has been at Vanderbilt University since 2000, where he is currently Professor of Biochemistry. |
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Robb Moses mosesr@ohsu.edu Bio Dr. Moses studies DNA repair and the cellular mechanisms responsible for genome stability. The model system his group is concentrating on is Fanconi anemia (FA), a rare recessive disorder which has increased rates of leukemia and solid tumors. The model studies are based on the sensitivity of FA cells to DNA crosslinking agents specifically, and the resulting chromosomal aberrations resulting from such DNA damage. The FA pathway is complex with thirteen identified proteins acting in concert with other cellular tumor suppressor proteins, including BRCA1 and the Bloom protein. Dr. Moses received his M.D. degree from the Johns Hopkins Medical School, doing a special fellowship while in training there, followed by post-doctoral research at the National Institutes of Health and Harvard Medical School before joining the faculty at Baylor college of Medicine in 1971. He has been Professor and Chair in the department of Molecular and Medical Genetics at OHSU since 1991. |
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Robert Turesky rxt07@health.state.ny.us Bio Dr. Robert J. Turesky has expertise in the area of xenobiotic metabolism of procarcinogens and biomonitoring of their metabolic by products, such as urinary metabolites, protein and DNA adducts, which are employed in human molecular epidemiology studies. The primary experimental technique that Dr. Turesky utilizes to characterize and quantitate biomarkers is mass spectrometry. Dr. Turesky received his Ph.D. from the M.I.T. Thereafter, he worked as a research investigator at the Nestle Research Center in Lausanne for 15 years, followed by 4 years as a Division Director at the National Center for Toxicological Research, Jefferson, AR, prior to arriving at the Wadsworth Center in 2004. His current position is Associate Professor, Department of Environmental Health and Toxicology, School of Public Health, State University of New York, Albany, and research investigator at the Wadsworth Center, New York State Department of Health. |