Available Technologies


283 available technologies

Novel PLD Inhibitors

Vanderbilt researchers have created the first isoform-selective phospholipase D (PLD) inhibitors. These highly potent inhibitors can significantly reduce PLD activity, creating a new class of anti-metastatic agents.

Highly Accurate Radio Chip Localization Technology

Summary: This technology, developed at Vanderbilt University's Institute for Software Integrated Systems, uses radio interferometry to locate tangible objects and attains, simultaneously, a higher degree of accuracy (within 3 centimeters), considerably longer range (up to 160 meters) and lower cost than other technologies.

Through the Tool Tracking for Friction Stir Welding

Utilizing force sensors mounted on the friction stir welding tool, Vanderbilt inventors have developed a technique to keep a weld tool on track. This technology is especially benefi cial in real time corrections for deviations in travel in the case of robotic FSW or "blind" welds. The technique is cost- effective in that no additional sensors such as cameras, thermocouples, acoustic emission receivers, etc. are required.

A Robotic System for Real-time Tumor Manipulation During Image Guided Breast Biopsy

Three types of technologies have been developed for assisting during breast biopsy procedures.

1) Many robotic systems have been developed to improve accuracy of needle insertions. Butthese systems do not compensate for tumor movement during the insertion. Hence multipleinsertions are typically required to successfully sample the tumor.
2) Steerable needle devices have been developed to guide the needle tip towards the tumor.Even though these systems may not require multiple insertions, they cause tissue damageinside the breast during steering of the needle.
3) Finite element methods have been developed to predict and compensate for tumormovement. The disadvantage with this technology is that geometric and mechanicalproperties of the breast are required for finite element analysis. The average computationaltime is approximately half an hour.

We developed a novel technology for guiding clinical breast biopsy. This system positions a tumor inline with the needle during real-time needle insertion procedures. This technology solves the following problems:

- Breast biopsies can be performed without multiple needle insertions
- Expedites breast biopsy procedures
- Does not need geometric or mechanical properties of the breast
- Tissue damage inside the breast is minimized

Serotonin 2B Receptor Antagonism to Prevent Heart Valve Disease

Vanderbilt researchers have developed a novel approach that could potentially prevent or slow the progression of DAVD at its earliest possible stages so as to greatly increase patient quality of life. The initial mechanism which triggers fibrotic lesion formation occurs by phenotypic modulation of the aortic valve interstitial cells (AVICs) to the constitutive myofibroblast phenotype, producing significant amounts of extracellular matrix, similar to fibrotic remodeling in other tissues. Thus, desired goal to prevent DAVD is to control the phenotype modulation by specifically inhibiting molecular mechanisms that are known to cause activation of AVICs. This is achieved by inhibiting transforming growth factor-

Diamond Triode Devices with a Diamond Microtip Emitter

This technology is a diamond triode for micro and power electronics. Diamond microtip field emitters are used in triode vacuum electronic devices, sensors and displays. Diamond triode devices having integral anode and grid structures are fabricated using a patented process. Ultra-sharp tips are formed on the emitters in the fabrication process in which diamond is deposited into mold cavities in a two-step deposition sequence. During deposition of the diamond, the carbon graphite content is carefully controlled to enhance emission performance. The tips or the emitters are treated by post-fabrication processes to further enhance performance.

Precision Pneumatic Robot for MRI-Guided Neurosurgery

At Vanderbilt University, a robotic steering mechanism for MRI-guided neurosurgical ablation has been developed. The small robot has submilimeter precision and is fully MRI compatible. It aims to replace current surgical practices with minimally invasive procedures in order to enhance the treatment of cancer and numerous neurological disorders such as epilepsy.

Ultrasonic Sensor for Non-intrusive Local Temperature, Transient Temperature and Heat Flux Measurements

An apparatus for measuring the temperature and heat flux of materials through the use of an ultrasonic sensor has been developed at Vanderbilt University. The sensor uses acoustic measurement techniques to determine the heat flux and temperature of material surfaces otherwise inaccessible in particular during system operation in order to enhance monitoring capabilities and reduce unsafe or impaired function due to extreme temperatures.

Flat-Cut Bit for Cranial Perforator

Inventors at Vanderbilt have developed a novel perforating drill bit for cranial surgery. Deep brain stimlation (DBS) has become a technique for the treatment of movement disorders, as well as obsessive compulsive disorders and epilespy. This cranial drill bit significantly improves the process of preparing the periphery around the cranial punch during electrode implantation, one of the critical steps during DBS surgery.

A peptide therapeutic for atherosclerosis that restores lipid and cholesterol homeostasis

Atherosclerosis is a serious health concern; leading to 1.5 million heart attacks in the US each year and 795,000 strokes. Vanderbilt researchers have developed a peptide therapeutic that reduces development of atherosclerosis by 63% in mice fed a Western diet. This peptide's unique mechanism attacks the problem at the level of gene expression, returning lipid synthesis to homeostatic control, while also reducing cholesterol and triglyceride levels and improving liver function.

Assay for Dopamine Neuron Viability Using C. Elegans

The loss of DA neurons is a major feature of Parkinson's disease and other neuro-generative disorders. Vanderbilt researchers have established an in vivo screen for DA neuron protective agents and genes using the nematode C. elegans. Using green fluorescent protein (GFP) expression in C. elegans DA neurons, researchers have established that the nematode is sensitive to the mammalian neurotoxins that target DA neurons in mammalian models, consistent with an environmentally triggered loss of DA neurons. They also demonstrate that agents that block the nematode DA transporter or genetic ablation of the DA transporters protect these DA neurons. Thus, researchers have established lines and conditions that can allow for the facile screening, in a high throughput format, for agents or genes that may protect DA neurons from exogenous or endogenous neurotoxin-induced cell death. The system should also be useful for identifying novel pathway controlling presynaptic DA neuron function with potential applications to Schizophrenia, ADHD and addiction, where altered DA signaling has been proposed.

New Insect Repellants Disrupt Olfactory Cues: A Strategy for Pest Protection

A multinational research team, led by Dr. L. J. Zwiebel of Vanderbilt University, has identified new compounds with potential as insect repellents. These compounds work by capitalizing on knowledge of how insect odorant receptors detect and respond to scents. Medicinal chemistry efforts have yielded a number of novel compounds that could short-circuit the insect olfactory system, essentially by over-stimulation, to effectively mask attractive odors. These compounds could be used to repel nuisance and disease-carrying insects away from humans and animals, as well as repel agricultural pests from crops or food storage facilities. Vanderbilt University is seeking commercial partners to develop the technology for agricultural uses.

Near-Infrared Dye with Large Stokes Shift for Simultaneous Multichannel in vivo Molecular Imaging

Fluorescent labels having near-infrared (NIR) emission wavelengths have the ability to penetrate tissue deeper than other emission wavelengths, providing enormous potential for non-invasive imaging applications. However, advancement of optical imaging (particularly NIR imaging) is hindered by the limitation of narrow Stokes shift of most infrared dyes currently available in the market. Vanderbilt researchers have developed a novel NIR dye (4-Sulfonir) for multichannel imaging that enables in vivo imaging of multiple targets due to its large Stokes shift. 4-Sulfonir with its unique large Stokes shift (~150 nm) and wide excitation spectrum could be used in parallel with other NIR dyes for imaging two molecular events simultaneously in one target.

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